Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM10 | O14672 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | MMP14 | P50281 | 1/20 | 0.38 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | PREP | P48147 | 2/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 6/20 | 0.36 |
| ▸ | CTSL | P07711 | 4/20 | 0.35 |
| ▸ | CTSB | P07858 | 3/20 | 0.35 |
| ▸ | CTSK | P43235 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CTSS | P25774 | 3/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9198396 | 0.82 | ABCC9 (0.39) | ABCB1 | |
| SCHEMBL9197783 | 0.80 | ABCB1 (0.34) | ABCB1 | |
| SCHEMBL9735028 | 0.80 | ABCC9 (0.37) | ABCB1 | |
| SCHEMBL9737142 | 0.71 | MAOB (0.42) | CYP3A4ALOX15ABCB1CTSLCTSB | |
| SCHEMBL9734265 | 0.69 | ABCC9 (0.39) | CYP3A4ALOX15ABCB1 | |
| SCHEMBL9734096 | 0.68 | ABCC9 (0.41) | CYP3A4ABCB1 | |
| SCHEMBL9735833 | 0.68 | CYP3A4 (0.38) | ADAM10MMP2MMP9MMP14ADAM17 | |
| SCHEMBL9198634 | 0.68 | ABCC9 (0.34) | ABCB1 | |
| SCHEMBL9733575 | 0.67 | ABCC9 (0.37) | ABCB1 | |
| SCHEMBL9736930 | 0.67 | MEN1 (0.32) | GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5130322-A | CHROMAN DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-07-14 | — | — | US | disclosed |
| EP-0415065-A1 | Chroman derivatives | MERCK PATENT GmbH (DE) | 1991-03-06 | — | — | EP | disclosed |