Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 2/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9736662 | 0.85 | DRD3 (0.34) | MEN1ALDH1A1KMT2ABACE1GAA | |
| SCHEMBL9197783 | 0.85 | ABCB1 (0.34) | MEN1KMT2ABACE1 | |
| SCHEMBL9735583 | 0.84 | OPRM1 (0.36) | — | |
| SCHEMBL9736615 | 0.84 | — | — | |
| SCHEMBL9735247 | 0.80 | ABCC9 (0.34) | MEN1ALDH1A1KMT2ABACE1 | |
| SCHEMBL9736968 | 0.74 | IDO1 (0.38) | ALDH1A1NPSR1 | |
| SCHEMBL9733240 | 0.74 | CYP11B2 (0.35) | MEN1ALDH1A1KMT2ANPSR1MAPT | |
| SCHEMBL9198396 | 0.73 | ABCC9 (0.39) | — | |
| SCHEMBL9735028 | 0.73 | ABCC9 (0.37) | BACE1 | |
| SCHEMBL9735574 | 0.71 | BACE1 (0.32) | MEN1ALDH1A1KMT2ABACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5130322-A | CHROMAN DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-07-14 | — | — | US | disclosed |
| EP-0415065-A1 | Chroman derivatives | MERCK PATENT GmbH (DE) | 1991-03-06 | — | — | EP | disclosed |