Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.50 |
| ▸ | DRD2 | P14416 | 5/20 | 0.49 |
| ▸ | DRD4 | P21917 | 2/20 | 0.49 |
| ▸ | DRD3 | P35462 | 2/20 | 0.49 |
| ▸ | HTR1A | P08908 | 3/20 | 0.48 |
| ▸ | HTR2B | P41595 | 3/20 | 0.48 |
| ▸ | HRH2 | P25021 | 4/20 | 0.48 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9551700 | 0.87 | HRH2 (0.59) | HRH2 | |
| SCHEMBL10689006 | 0.86 | HRH2 (0.61) | HRH2 | |
| SCHEMBL30597717 | 0.86 | HRH2 (0.61) | HRH2 | |
| SCHEMBL10527698 | 0.86 | HRH2 (0.61) | HRH2 | |
| SCHEMBL10679839 | 0.86 | HRH2 (0.61) | HRH2 | |
| SCHEMBL5288663 | 0.86 | HRH2 (0.61) | HRH2 | |
| SCHEMBL15012021 | 0.85 | SIGMAR1 (0.51) | SIGMAR1DRD2DRD4DRD3HTR1A | |
| SCHEMBL9734996 | 0.85 | SIGMAR1 (0.51) | SIGMAR1DRD2DRD4DRD3HTR1A | |
| SCHEMBL22794233 | 0.84 | NPC1 (0.53) | SIGMAR1DRD2HTR1AHTR2BTLR7 | |
| SCHEMBL9638384 | 0.84 | ALDH1A1 (0.63) | DRD2DRD4DRD3HTR1AHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5112866-A | Sulfonylfluorides as intermediates, also useful in treatment of bone disorders, antisecretory, antiulcer | ORTHO PHARMACEUTICAL CORPORATION (US) | 1992-05-12 | — | — | US | disclosed |
| EP-0358438-A2 | Ethanesulfonamide derivatives | ORTHO PHARMACEUTICAL CORPORATION (US) | 1990-03-14 | — | — | EP | disclosed |
| US-4874771-A | ANTISECRETORY, ANTIULCER AGENTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1989-10-17 | — | — | US | disclosed |