Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 18/20 | 0.64 |
| ▸ | AKR1A1 | P14550 | 2/20 | 0.64 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.64 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL4560793 | 0.94 | AKR1B1 (0.66) | AKR1B1AKR1A1AKR1B10GLO1 | |
| SCHEMBL21938648 | 0.81 | AKR1B1 (0.78) | AKR1B1AKR1A1AKR1B10GLO1 | |
| SCHEMBL20696627 | 0.79 | AKR1B1 (0.78) | AKR1B1AKR1A1AKR1B10GLO1 | |
| Zopolrestat SCHEMBL8505122 | 0.78 | AKR1B1 (1.00) | AKR1B1AKR1A1AKR1B10GLO1 | |
| Zopolrestat SCHEMBL49012 | 0.78 | AKR1B1 (1.00) | AKR1B1AKR1A1AKR1B10GLO1 | |
| Zopolrestat SCHEMBL29353641 | 0.78 | AKR1B1 (1.00) | AKR1B1AKR1A1AKR1B10GLO1 | |
| Zopolrestat SCHEMBL8129027 | 0.77 | AKR1B1 (0.98) | AKR1B1AKR1A1AKR1B10GLO1 | |
| Zopolrestat SCHEMBL7565103 | 0.77 | AKR1B1 (0.84) | AKR1B1AKR1A1AKR1B10GLO1 | |
| Zopolrestat SCHEMBL8129830 | 0.77 | AKR1B1 (0.83) | AKR1B1AKR1A1AKR1B10GLO1 | |
| SCHEMBL4560794 | 0.77 | AKR1B1 (0.69) | AKR1B1AKR1A1AKR1B10GLO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190192691-A1 | REGULATED BIOCIRCUIT SYSTEMS | OBSIDIAN THERAPEUTICS, INC. | 2019-06-27 | — | — | US | disclosed |
| WO-1992003432-A1 | 3-(5-TRIFLUOROMETHYLBENZOTHIAZOL-2-YLMETHYL)-4-OXO-3H-PHYTHALAZIN-1-YLACETIC ACID MONOHYDRATE | PFIZER INC. (US) | 1992-03-05 | — | — | WO | disclosed |