Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ALPG | P10696 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | NPY1R | P25929 | 1/20 | 0.32 |
| ▸ | NPY2R | P49146 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28711319 | 0.70 | ALDH1A1 (0.44) | GAAHTTCYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL5346537 | 0.69 | CYP3A4 (0.34) | CYP3A4CYP2C19NPSR1MEN1KMT2A | |
| SCHEMBL9737885 | 0.69 | CYP3A4 (0.39) | HTTCYP3A4CYP2C19MEN1KMT2A | |
| SCHEMBL9737899 | 0.69 | CYP3A4 (0.39) | HTTCYP3A4CYP2C19MEN1KMT2A | |
| SCHEMBL5338740 | 0.68 | CYP3A4 (0.34) | CYP3A4CYP2C19NPSR1MEN1KMT2A | |
| SCHEMBL24308934 | 0.67 | HTT (0.41) | GAAHTTCYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL11574122 | 0.64 | HPGD (0.48) | GAAHTTALDH1A1MAPTALOX12 | |
| SCHEMBL778610 | 0.64 | SMN1; SMN2 (0.52) | GAAHTTCYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL778386 | 0.64 | SMN1; SMN2 (0.43) | GAAHTTCYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL24817133 | 0.63 | SMN1; SMN2 (0.42) | GAAHTTCYP3A4CYP2C19ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0251164-B1 | NEW CHIRAL PHOSPHINOPYRROLIDINE COMPOUNDS AND THEIR USE FOR ASYMETRIC SYNTHESIS OF OPTICALLY ACTIVE COMPOUNDS | Achiwa, Kazuo (JP) | 1992-12-16 | — | — | EP | disclosed |
| US-4879389-A | HYDROGENATION CATALYSTS | ACHIWA KAZUO (JP) | 1989-11-07 | — | — | US | disclosed |
| EP-0251164-A2 | New chiral phosphinopyrrolidine compounds and their use for asymetric synthesis of optically active compounds | Achiwa, Kazuo (JP) | 1988-01-07 | — | — | EP | disclosed |