Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 10/20 | 0.41 |
| ▸ | CA9 | Q16790 | 10/20 | 0.41 |
| ▸ | CA2 | P00918 | 8/20 | 0.41 |
| ▸ | CA7 | P43166 | 6/20 | 0.41 |
| ▸ | CA1 | P00915 | 6/20 | 0.41 |
| ▸ | CA4 | P22748 | 4/20 | 0.41 |
| ▸ | RET | P07949 | 2/20 | 0.37 |
| ▸ | GRK5 | P34947 | 2/20 | 0.37 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.37 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | LTK | P29376 | 1/20 | 0.33 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.33 |
| ▸ | CDK8 | P49336 | 1/20 | 0.33 |
| ▸ | PRKX | P51817 | 1/20 | 0.33 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7288582 | 0.84 | CA12 (0.33) | CA12CA9CA2CA7CA1 | |
| SCHEMBL7291172 | 0.82 | CA12 (0.37) | CA12CA9CA2CA7CA1 | |
| SCHEMBL7281187 | 0.82 | CA12 (0.46) | CA12CA9CA2CA7CA1 | |
| SCHEMBL7287741 | 0.82 | RET (0.36) | CA12CA9CA2CA7CA1 | |
| SCHEMBL7012037 | 0.82 | ELANE (0.41) | CA12CA9CA2CA7CA1 | |
| SCHEMBL7281556 | 0.80 | ELANE (0.39) | CA12CA9CA2CA7CA1 | |
| SCHEMBL7004936 | 0.80 | ELANE (0.44) | CA12CA9CA2CA7CA1 | |
| SCHEMBL7280069 | 0.79 | MCL1 (0.35) | CA12CA9CA2CA7CA1 | |
| SCHEMBL7278571 | 0.78 | CA12 (0.39) | CA12CA9CA2CA7CA1 | |
| SCHEMBL7278053 | 0.78 | CA2 (0.40) | CA12CA9CA2CA7CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5128339-A | Emphysema, rheumatoid arthritis, pancreatitis | STERLING WINTHROP INC. (US) | 1992-07-07 | — | — | US | disclosed |