Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 17/20 | 0.44 |
| ▸ | CA12 | O43570 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | CA9 | Q16790 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA4 | P22748 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9148786 | 0.86 | CA12 (0.39) | ELANECA12CA2CA9CA1 | |
| SCHEMBL7247959 | 0.85 | ELANE (0.40) | ELANECA12CA2CA9CA1 | |
| SCHEMBL7291109 | 0.83 | CA2 (0.35) | ELANECA12CA2CA9CA1 | |
| SCHEMBL7291529 | 0.81 | CA12 (0.40) | ELANECA12CA2CA9CA1 | |
| SCHEMBL7291629 | 0.80 | PKM (0.44) | CA12CA2CA9CA1CA4 | |
| SCHEMBL7290897 | 0.80 | ALDH1A1 (0.46) | ELANECA12CA2CA9CA1 | |
| SCHEMBL9737868 | 0.80 | CA12 (0.41) | CA12CA2CA9CA1CA4 | |
| SCHEMBL7290687 | 0.79 | CA12 (0.37) | ELANECA12CA2CA9CA1 | |
| SCHEMBL12261822 | 0.78 | CA12 (0.44) | CA12CA2CA9CA1CA4 | |
| SCHEMBL7012037 | 0.78 | ELANE (0.41) | ELANECA12CA2CA9CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030114449-A1 | SACCHARIN DERIVATIVES AS ORALLY ACTIVE ELASTASE INHIBITORS | SANOFI-SYNTHELABO (FR) | 2003-06-19 | — | — | US | disclosed |
| EP-0547708-B1 | Saccharin derivative proteolytic enzyme inhibitors | SANOFI SYNTHELABO (FR) | 2003-02-26 | — | — | EP | disclosed |
| EP-0626378-B1 | Saccharin derivative proteolytic enzyme inhibitors | SANOFI SYNTHELABO (FR) | 2003-01-22 | — | — | EP | disclosed |
| EP-1255756-A1 | SACCHARIN DERIVATIVES AS ORALLY ACTIVE ELASTASE INHIBITORS | SANOFI-SYNTHELABO (FR) | 2002-11-13 | — | — | EP | disclosed |
| WO-2001044245-A1 | SACCHARIN DERIVATIVES AS ORALLY ACTIVE ELASTASE INHIBITORS | SANOFI-SYNTHELABO (FR) | 2001-06-21 | — | — | WO | disclosed |
| EP-0550111-B1 | 2-Saccharinylmethyl heterocyclic carboxylates useful as proteolytic enzyme inhibitors and pharmaceutical compositions containing them | SANOFI SA (FR) | 1999-04-14 | — | — | EP | disclosed |
| US-5874432-A | Saccharin derivatives useful as proteolytic enzyme inhibitors and compositions and method of use thereof | SANOFI (FR) | 1999-02-23 | — | — | US | disclosed |
| US-5856349-A | 2-Saccharinylmethyl heterocyclic carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof | SANOFI (FR) | 1999-01-05 | — | — | US | disclosed |
| US-5783589-A | 2-saccharinylmethyl aryl and arloxy acetates useful as proteolytic enzyme inhibitors and compositions and method of use thereof | SANOFI (FR) | 1998-07-21 | — | — | US | disclosed |
| US-5773456-A | EMPHYSEMA, RHEUMATOID ARTHRITIS AND PANCREATITIS | SANOFI (FR) | 1998-06-30 | — | — | US | disclosed |
| EP-0550111-A1 | 2-Saccharinylmethyl heterocyclic carboxylates useful as proteolytic enzyme inhibitors and pharmaceutical compositions containing them | STERLING WINTHROP INC. (US) | 1993-07-07 | — | — | EP | disclosed |
| EP-0550112-A1 | 2-Saccharinylmethyl aryl and aryloxy acetates useful as proteolytic enzyme inhibitors and pharmaceutical compositions contaning them | STERLING WINTHROP INC. (US) | 1993-07-07 | — | — | EP | disclosed |
| EP-0549073-A1 | Novel 2-saccharinylmethyl and 4,5,6,7-tetrahydro-2-saccharinylmethyl phosphates, phosphonates and phosphinates useful as proteolytic enzyme inhibitors and compositions and method of use thereof | STERLING WINTHROP INC. (US) | 1993-06-30 | — | — | EP | disclosed |
| EP-0547708-A1 | Saccharin derivative proteolytic enzyme inhibitors | STERLING WINTHROP INC. (US) | 1993-06-23 | — | — | EP | disclosed |
| EP-0542372-A1 | 2-Substituted saccharin derivative proteolytic enzyme inhibitors | STERLING WINTHROP INC. (US) | 1993-05-19 | — | — | EP | disclosed |
| EP-0542371-A1 | Saccharin derivative proteolytic enzyme inhibitors | STERLING WINTHROP INC. (US) | 1993-05-19 | — | — | EP | disclosed |
| US-5187173-A | Degenerative diseases such as emphysema, rheumatoid arthritis, pancreatitis, cyctic fibrosis and skin disorders | STERLING WINTHROP INC. (US) | 1993-02-16 | — | — | US | disclosed |
| US-5128339-A | Emphysema, rheumatoid arthritis, pancreatitis | STERLING WINTHROP INC. (US) | 1992-07-07 | — | — | US | disclosed |
| EP-0483928-A1 | 2-Saccharinylmethyl aryl carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use | STERLING WINTHROP INC. (US) | 1992-05-06 | — | — | EP | disclosed |
| WO-1990013549-A1 | SACCHARIN DERIVATIVES USEFUL AS PROTEOLYTIC ENZYME INHIBITORS AND PREPARATION THEREOF | STERLING WINTHROP INC. (US) | 1990-11-15 | — | — | WO | disclosed |