Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 4/20 | 0.47 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.45 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9844151 | 0.83 | AGTR1 (0.47) | AGTR1AGTR2 | |
| SCHEMBL9844033 | 0.82 | AGTR1 (0.50) | AGTR1AGTR2 | |
| SCHEMBL9843702 | 0.81 | AGTR1 (0.48) | PPARGAGTR1AGTR2 | |
| SCHEMBL9401976 | 0.78 | AGTR1 (0.52) | PPARGAGTR1AGTR2KCNH2 | |
| SCHEMBL9843949 | 0.78 | AGTR1 (0.58) | AGTR1AGTR2 | |
| SCHEMBL9843777 | 0.78 | AGTR1 (0.51) | AGTR1AGTR2 | |
| SCHEMBL13024751 | 0.77 | AGTR1 (0.53) | AGTR1AGTR2 | |
| SCHEMBL9843791 | 0.77 | AGTR1 (0.49) | PPARGAGTR1AGTR2 | |
| SCHEMBL3630525 | 0.75 | AGTR1 (0.52) | AGTR1AGTR2 | |
| SCHEMBL13474406 | 0.75 | AGTR1 (0.51) | AGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5100897-A | Hypotensive agents, congestive heart failure, ocular hypertension | MERCK & CO., INC. (US) | 1992-03-31 | — | — | US | disclosed |
| EP-0419048-A2 | Substituted pyrimidinones as angiotensin II antagonists | MERCK & CO. INC. (US) | 1991-03-27 | — | — | EP | disclosed |