Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.36 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | PLAU | P00749 | 1/20 | 0.36 |
| ▸ | PLAT | P00750 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8539616 | 0.82 | SLC6A2 (0.56) | ROCK1MEN1NPC1RAB9AKMT2A | |
| SCHEMBL9738305 | 0.73 | ROCK1 (0.47) | ROCK1MEN1NPC1RAB9AKMT2A | |
| SCHEMBL8539129 | 0.71 | ROCK1 (0.47) | ROCK1MEN1NPC1RAB9AKMT2A | |
| SCHEMBL1400791 | 0.68 | NPC1 (0.63) | ROCK1MEN1NPC1RAB9AKMT2A | |
| SCHEMBL8836016 | 0.66 | SPHK2 (0.51) | ROCK1MEN1NPC1RAB9AKMT2A | |
| SCHEMBL8836009 | 0.66 | LTA4H (0.53) | ROCK1MEN1NPC1RAB9AKMT2A | |
| SCHEMBL3979896 | 0.66 | ROCK1 (0.58) | ROCK1MEN1NPC1RAB9AKMT2A | |
| SCHEMBL21244774 | 0.65 | NPC1 (0.56) | ROCK1MEN1NPC1RAB9AKMT2A | |
| SCHEMBL28665938 | 0.65 | ROCK1 (0.71) | ROCK1MEN1NPC1RAB9AKMT2A | |
| SCHEMBL3193186 | 0.65 | MAPK14 (0.61) | ROCK1MEN1NPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5102891-A | Useful for treating various memory dysfunctions such as alzheimer's disease | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1992-04-07 | — | — | US | disclosed |