Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 1/20 | 0.58 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.48 |
| ▸ | MAOB | P27338 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | AS3MT | Q9HBK9 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1400791 | 0.82 | NPC1 (0.63) | ROCK1ALOX5RAB9ANPC1MEN1 | |
| SCHEMBL3193186 | 0.81 | MAPK14 (0.61) | ROCK1ALOX5RAB9ANPC1MEN1 | |
| SCHEMBL17602338 | 0.81 | ROCK1 (0.64) | ROCK1ALOX5RAB9ANPC1MEN1 | |
| SCHEMBL27639042 | 0.79 | ALOX5 (0.55) | ROCK1ALOX5RAB9ANPC1MEN1 | |
| SCHEMBL8362532 | 0.79 | SRD5A2 (0.55) | ROCK1ALOX5RAB9ANPC1MEN1 | |
| SCHEMBL21244774 | 0.78 | NPC1 (0.56) | ROCK1ALOX5RAB9ANPC1MEN1 | |
| SCHEMBL17602263 | 0.78 | MEN1 (0.56) | ROCK1ALOX5RAB9ANPC1MEN1 | |
| SCHEMBL5483649 | 0.78 | SRD5A2 (0.57) | ROCK1ALOX5RAB9ANPC1MEN1 | |
| SCHEMBL4191518 | 0.77 | MEN1 (0.54) | ROCK1ALOX5RAB9ANPC1MEN1 | |
| SCHEMBL7927758 | 0.76 | PPARD (0.56) | ROCK1ALOX5RAB9ANPC1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5565579-A | NEUROPROTECTIVE AGENT | HOECHST MARION ROUSSEL INC. (US) | 1996-10-15 | — | — | US | claimed |
| CN-100579963-C | Process for preparing N-amino substituted heterocyclic compounds | AVENTIS PHARMA INC | 2010-01-13 | — | — | CN | disclosed |
| EP-1678135-B1 | PROCESS FOR THE PREPARATION OF N-AMINO SUBSTITUTED HETEROCYCLIC COMPOUNDS | AVENTIS PHARMA INC (US) | 2009-05-13 | — | — | EP | disclosed |
| CN-101391976-A | Process for preparing N-amino substituted heterocyclic compounds | AVENTIS PHARMA INC (US) | 2009-03-25 | — | — | CN | disclosed |
| CN-1890213-A | Process for preparing N-amino substituted heterocyclic compounds | AVENTIS PHARMA INC (US) | 2007-01-03 | — | — | CN | disclosed |
| US-7112682-B2 | Process for the preparation of N-amino substituted heterocyclic compounds | AVENTIS PHARMACEUTICALS INC. (US) | 2006-09-26 | — | — | US | disclosed |
| EP-1678135-A1 | PROCESS FOR THE PREPARATION OF N-AMINO SUBSTITUTED HETEROCYCLIC COMPOUNDS | Aventis Pharmaceuticals, Inc. (US) | 2006-07-12 | — | — | EP | disclosed |
| US-20050101654-A1 | Process for the preparation of N-amino substituted heterocyclic compounds | AVENTIS PHARMACEUTICALS INC. (US) | 2005-05-12 | — | — | US | disclosed |
| WO-2005035496-A1 | PROCESS FOR THE PREPARATION OF N-AMINO SUBSTITUTED HETEROCYCLIC COMPOUNDS | AVENTIS PHARMACEUTICALS INC. (US) | 2005-04-21 | — | — | WO | disclosed |
| EP-0468401-B1 | 1-(Substituted pyridinylamino)-1H-indol-5-yl substituted carbamates, a process for their preparation and their use as medicaments | HOECHST MARION ROUSSEL INC (US) | 1998-09-16 | — | — | EP | disclosed |
| US-5646300-A | NEUROPROTECTIVE AGENTS | HOECHST MARION ROUSSEL, INC. (US) | 1997-07-08 | — | — | US | disclosed |
| US-5591866-A | NEUROPROTECTIVE AGENTS | HOECHST MARION ROUSSEL INC. (US) | 1997-01-07 | — | — | US | disclosed |
| US-5565579-A | NEUROPROTECTIVE AGENT | HOECHST MARION ROUSSEL INC. (US) | 1996-10-15 | — | — | US | disclosed |
| EP-0563916-B1 | (1H-Indol-1-yl)-2-(amino)acetamides and related (1H-indol-1-yl)-(aminoalkyl)amides, intermediates and a process for their preparation and their use as medicaments | HOECHST ROUSSEL PHARMA (US) | 1995-08-16 | — | — | EP | disclosed |
| US-5319096-A | Neuroprotective agent | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1994-06-07 | — | — | US | disclosed |
| EP-0563916-A1 | (1H-Indol-1-yl)-2-(amino)acetamides and related (1H-indol-1-yl)-(aminoalkyl)amides, intermediates and a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-10-06 | — | — | EP | disclosed |
| US-5102891-A | Useful for treating various memory dysfunctions such as alzheimer's disease | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1992-04-07 | — | — | US | disclosed |
| EP-0468401-A2 | 1-(Substituted pyridinylamino)-1H-indol-5-yl substituted carbamates, a process and intermediates for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-01-29 | — | — | EP | disclosed |
| US-5039811-A | Analgesics, antidepressants, memory activators; condensation, reduction | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1991-08-13 | — | — | US | disclosed |
| US-4970218-A | ANALGESIC, ANTIDEPRESSANT, MEMORY ENHANCEMENT | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1990-11-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050101654-A1 | Process for the preparation of N-amino substituted heterocyclic compounds | AADAT, KMO, KYNU | ROCK1 1949/4885ALOX5 1524/4885RAB9A 1939/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.