Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 7/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | RXRA | P19793 | 2/20 | 0.52 |
| ▸ | OXER1 | Q8TDS5 | 2/20 | 0.52 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.52 |
| ▸ | PPARD | Q03181 | 5/20 | 0.41 |
| ▸ | PPARA | Q07869 | 5/20 | 0.41 |
| ▸ | TERT | O14746 | 3/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.41 |
| ▸ | F7 | P08709 | 3/20 | 0.41 |
| ▸ | F3 | P13726 | 3/20 | 0.41 |
| ▸ | BLM | P54132 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | FABP4 | P15090 | 3/20 | 0.41 |
| ▸ | TOP1 | P11387 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9201431 | 1.00 | PPARG (0.52) | PPARGMAPTCYP19A1ALDH1A1RXRA | |
| SCHEMBL9201429 | 1.00 | PPARG (0.52) | PPARGMAPTCYP19A1ALDH1A1RXRA | |
| SCHEMBL13931836 | 0.87 | PPARG (0.55) | PPARGMAPTCYP19A1ALDH1A1RXRA | |
| SCHEMBL8458410 | 0.84 | PPARG (0.63) | PPARGMAPTCYP19A1ALDH1A1OXER1 | |
| SCHEMBL27534724 | 0.83 | PPARG (0.48) | PPARGMAPTCYP19A1ALDH1A1RXRA | |
| SCHEMBL1786831 | 0.82 | ALDH1A1 (0.39) | PPARGMAPTCYP19A1ALDH1A1RXRA | |
| SCHEMBL1786833 | 0.82 | ALDH1A1 (0.39) | PPARGMAPTCYP19A1ALDH1A1RXRA | |
| SCHEMBL12320543 | 0.82 | PPARG (0.52) | PPARGMAPTCYP19A1ALDH1A1RXRA | |
| SCHEMBL176453 | 0.80 | PPARG (0.64) | PPARGMAPTCYP19A1ALDH1A1RXRA | |
| SCHEMBL2540034 | 0.80 | PPARG (0.64) | PPARGMAPTCYP19A1ALDH1A1RXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5100889-A | Thromboxane A2 receptor antagonists, thromboxane synthetase inhibitor | E. R. SQUIBB & SONS, INC. (US) | 1992-03-31 | — | — | US | disclosed |
| EP-0374952-A2 | 7-Oxabicycloheptyl substituted heterocyclic amide prostaglandin analogs useful in the treatment of thrombotic and vasospastic disease | E.R. SQUIBB & SONS, INC. (US) | 1990-06-27 | — | — | EP | disclosed |