Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 5/20 | 0.53 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.53 |
| ▸ | TMIGD3 | P0DMS9 | 4/20 | 0.53 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.52 |
| ▸ | AXL | P30530 | 2/20 | 0.46 |
| ▸ | MERTK | Q12866 | 2/20 | 0.46 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.45 |
| ▸ | PDE8A | O60658 | 1/20 | 0.45 |
| ▸ | CDK1 | P06493 | 2/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9738479 | 0.88 | AXL (0.53) | ADORA2AADORA1TMIGD3ADORA2BAXL | |
| SCHEMBL9739623 | 0.87 | ADORA2A (0.55) | ADORA2AADORA1TMIGD3ADORA2BPDE8A | |
| SCHEMBL9738619 | 0.84 | PDE4A (0.46) | ADORA2AADORA1AXLMERTKFLT3 | |
| SCHEMBL7209250 | 0.82 | ADORA2A (0.69) | ADORA2AADORA1TMIGD3ADORA2BFLT3 | |
| SCHEMBL9738975 | 0.81 | ADORA2A (0.65) | ADORA2AADORA1AXLMERTKFLT3 | |
| SCHEMBL3959823 | 0.79 | PDE8A (0.67) | ADORA2AADORA1PDE8ACDK1PDE4A | |
| SCHEMBL23763962 | 0.79 | ADORA2A (0.55) | ADORA2AADORA1TMIGD3ADORA2BCDK1 | |
| SCHEMBL9739172 | 0.79 | ADORA2A (0.51) | ADORA2AADORA1AXLMERTKFLT3 | |
| SCHEMBL9739774 | 0.78 | ADORA2A (0.55) | ADORA2AADORA1TMIGD3ADORA2BPDE4A | |
| SCHEMBL3957420 | 0.77 | AXL (0.51) | ADORA2AADORA1ADORA2BAXLMERTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5110818-A | Antiepileptic agents | CIBA-GEIGY CORPORATION (US) | 1992-05-05 | — | — | US | disclosed |
| EP-0363320-A2 | Substituted 9H purine | CIBA-GEIGY AG (CH) | 1990-04-11 | — | — | EP | disclosed |