Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 2/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9738592 | 0.86 | HSD11B1 (0.41) | NPC1POLBPARP1MEN1KMT2A | |
| SCHEMBL9738986 | 0.82 | RXFP1 (0.42) | NPC1POLBPARP1RXFP1MEN1 | |
| SCHEMBL9738530 | 0.78 | NPC1 (0.35) | NPC1POLBPARP1MEN1KMT2A | |
| SCHEMBL9700664 | 0.77 | NPC1 (0.33) | NPC1POLBPARP1RXFP1HTT | |
| SCHEMBL9738647 | 0.76 | HSD11B1 (0.43) | NPC1POLBRXFP1MEN1KMT2A | |
| SCHEMBL9739760 | 0.75 | OPRL1 (0.38) | NPC1POLBMEN1KMT2AHTT | |
| SCHEMBL9197464 | 0.75 | NPC1 (0.35) | NPC1POLBPARP1RXFP1MEN1 | |
| SCHEMBL9740491 | 0.74 | MEN1 (0.40) | NPC1POLBMEN1KMT2AHTT | |
| SCHEMBL9209781 | 0.74 | NPC1 (0.34) | NPC1POLBPARP1RXFP1MEN1 | |
| SCHEMBL9203496 | 0.74 | NPC1 (0.61) | NPC1POLBPARP1RXFP1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992016529-A1 | NOVEL ISOINDOLE DERIVATIVES AND MEDICAMENTS CONTAINING THEM | BOEHRINGER MANNHEIM GMBH (DE) | 1992-10-01 | — | — | WO | disclosed |