Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 5/20 | 0.73 |
| ▸ | MCL1 | Q07820 | 5/20 | 0.73 |
| ▸ | MAOA | P21397 | 4/20 | 0.57 |
| ▸ | MAOB | P27338 | 4/20 | 0.57 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | NSD2 | O96028 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TTR | P02766 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1038715 | 0.91 | BCL2 (0.80) | BCL2MCL1MAOAMAOBADORA2A | |
| SCHEMBL9925983 | 0.89 | BCL2 (0.77) | BCL2MCL1MAOAMAOBADORA2A | |
| SCHEMBL7905103 | 0.85 | BCL2 (0.70) | BCL2MCL1MAOAMAOBMAPT | |
| SCHEMBL12957364 | 0.83 | BCL2 (0.69) | BCL2MCL1MAOAMAOBADORA2A | |
| SCHEMBL9239364 | 0.80 | BCL2 (0.47) | BCL2MCL1MAPTMAPK1MEN1 | |
| SCHEMBL8653360 | 0.79 | BCL2 (0.73) | BCL2MCL1MAOAMAOBMAPT | |
| SCHEMBL12956976 | 0.79 | BCL2 (0.76) | BCL2MCL1MAOAMAOBMAPT | |
| SCHEMBL9846537 | 0.78 | ADORA2A (0.65) | BCL2MCL1MAOAMAOBADORA2A | |
| SCHEMBL9846493 | 0.78 | ADORA2A (0.65) | BCL2MCL1MAOAMAOBADORA2A | |
| SCHEMBL9320566 | 0.77 | MAOA (0.61) | BCL2MCL1MAOAMAOBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0344110-B1 | SUBSTITUTED NAPHTHACENES-5,12-DIONES AND THEIR USE | CIBA-GEIGY AG (CH) | 1992-09-16 | — | — | EP | disclosed |
| US-5001243-A | Substituted naphthacene-5, 12-diones | CIBA-GEIGY CORPORATION (US) | 1991-03-19 | — | — | US | disclosed |
| EP-0344110-A2 | Substituted naphthacenes-5,12-diones and their use | CIBA-GEIGY AG (CH) | 1989-11-29 | — | — | EP | disclosed |