Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 6/20 | 0.34 |
| ▸ | CNR1 | P21554 | 5/20 | 0.34 |
| ▸ | FAAH | O00519 | 3/20 | 0.34 |
| ▸ | ABHD12 | Q8N2K0 | 2/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
| ▸ | SLC33A1 | O00400 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9739505 | 0.99 | RIPK1 (0.37) | RIPK1ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL9738796 | 0.90 | AGTR1 (0.38) | RIPK1SLC33A1 | |
| SCHEMBL9740009 | 0.89 | AGTR1 (0.39) | RIPK1 | |
| SCHEMBL9739090 | 0.89 | AGTR1 (0.44) | CNR2CNR1 | |
| SCHEMBL9738079 | 0.88 | RIPK1 (0.34) | RIPK1ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL9738675 | 0.88 | SLC33A1 (0.36) | RIPK1SLC33A1 | |
| SCHEMBL9738627 | 0.88 | AGTR1 (0.44) | — | |
| SCHEMBL9738099 | 0.87 | RIPK1 (0.35) | RIPK1ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL9738918 | 0.86 | SLC33A1 (0.34) | RIPK1SLC33A1 | |
| SCHEMBL9738503 | 0.86 | TRPV1 (0.36) | ALDH1A1SMN1; SMN2MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992005161-A1 | 1,3,5-TRISUBSTITUTED-1,2,4-TRIAZOLE COMPOUNDS FOR TREATMENT OF CIRCULATORY DISORDERS | G.D. SEARLE & CO. (US) | 1992-04-02 | — | — | WO | claimed |