Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 7/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.37 |
| ▸ | NMT2 | O60551 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9739966 | 0.86 | ALOX5 (0.53) | ALOX5L3MBTL1KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL9739893 | 0.85 | ALOX5 (0.54) | ALOX5RAB9AMAPTNPC1L3MBTL1 | |
| SCHEMBL10738818 | 0.78 | RAB9A (0.60) | ALOX5RAB9AMAPTNPC1L3MBTL1 | |
| SCHEMBL6871537 | 0.77 | RAB9A (0.62) | RAB9AMAPTNPC1L3MBTL1KDM4E | |
| SCHEMBL24756041 | 0.76 | RAB9A (0.54) | RAB9AMAPTNPC1L3MBTL1KDM4E | |
| SCHEMBL10739810 | 0.76 | RAB9A (0.58) | RAB9AMAPTNPC1L3MBTL1KDM4E | |
| SCHEMBL6871943 | 0.76 | RAB9A (0.60) | ALOX5RAB9AMAPTNPC1L3MBTL1 | |
| SCHEMBL10745259 | 0.75 | ALOX5 (0.48) | ALOX5RAB9AMAPTNPC1L3MBTL1 | |
| SCHEMBL3609288 | 0.73 | RAB9A (0.50) | ALOX5RAB9AMAPTNPC1L3MBTL1 | |
| SCHEMBL10742515 | 0.72 | RAB9A (0.46) | RAB9AMAPTNPC1L3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0200443-B1 | LIPOXYGENASE INHIBITORS | MERCK FROSST CANADA INC. (CA) | 1989-03-01 | — | — | EP | claimed |
| EP-0200443-A1 | Lipoxygenase inhibitors | MERCK FROSST CANADA INC. (CA) | 1986-11-05 | — | — | EP | claimed |
| US-5087638-A | Inhibitors of mammalian leukotriene biosynthesis | MERCK FROSST CANADA, INC. (CA) | 1992-02-11 | — | — | US | disclosed |
| EP-0338782-A1 | Benzofuran derivatives | MERCK FROSST CANADA INC. (CA) | 1989-10-25 | — | — | EP | disclosed |
| US-4863958-A | TREATING ALLERGIC CONDITIONS, ASTHMA, CARDIOVASCULAR DISORDERS, AND INFLAMMATION | MERCK FROSST CANADA, INC. (CA) | 1989-09-05 | — | — | US | disclosed |
| EP-0165810-B1 | BENZOFURAN AND BENZOTHIOPHENE DERIVATIVES, THEIR USE IN INHIBITING MAMMALIAN LEUKOTRIENE BIOSYNTHESIS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE DERIVATIVES | MERCK FROSST CANADA INC. (CA) | 1989-08-23 | — | — | EP | disclosed |
| EP-0200443-B1 | LIPOXYGENASE INHIBITORS | MERCK FROSST CANADA INC. (CA) | 1989-03-01 | — | — | EP | disclosed |
| US-4663347-A | ANTIINFLAMMATORY, ANTIALLERGENS, CARDIOVASCULAR | MERCK FROSST CANADA, INC. (CA) | 1987-05-05 | — | — | US | disclosed |
| EP-0200443-A1 | Lipoxygenase inhibitors | MERCK FROSST CANADA INC. (CA) | 1986-11-05 | — | — | EP | disclosed |
| EP-0165810-A2 | Benzofuran and benzothiophene derivatives, their use in inhibiting mammalian leukotriene biosynthesis, and pharmaceutical compositions containing these derivatives | MERCK FROSST CANADA INC. (CA) | 1985-12-27 | — | — | EP | disclosed |