Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 12/20 | 0.42 |
| ▸ | TLR7 | Q9NYK1 | 5/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27742843 | 0.87 | TLR8 (0.44) | TLR8TLR7NOS2 | |
| SCHEMBL28330927 | 0.82 | TLR8 (0.37) | TLR8TLR7ADORA1NOS2 | |
| SCHEMBL9738954 | 0.81 | ADORA2A (0.40) | TLR8TLR7ADORA2AADORA2BADORA1 | |
| SCHEMBL9843662 | 0.78 | MAPT (0.37) | TLR8TLR7 | |
| SCHEMBL9739003 | 0.78 | TLR8 (0.36) | TLR8TLR7 | |
| SCHEMBL30035562 | 0.75 | TLR8 (0.59) | TLR8TLR7 | |
| SCHEMBL20242690 | 0.75 | TLR8 (0.59) | TLR8TLR7 | |
| SCHEMBL13531385 | 0.74 | TLR8 (0.43) | TLR8TLR7 | |
| SCHEMBL22745738 | 0.72 | RAB9A (0.47) | TLR8TLR7 | |
| SCHEMBL16229363 | 0.71 | TLR8 (0.65) | TLR8TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5100897-A | Hypotensive agents, congestive heart failure, ocular hypertension | MERCK & CO., INC. (US) | 1992-03-31 | — | — | US | disclosed |
| EP-0419048-A2 | Substituted pyrimidinones as angiotensin II antagonists | MERCK & CO. INC. (US) | 1991-03-27 | — | — | EP | disclosed |