Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 15/20 | 0.56 |
| ▸ | SSTR5 | P35346 | 4/20 | 0.50 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | MLNR | O43193 | 1/20 | 0.46 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.46 |
| ▸ | EED | O75530 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HLA-A | P04439 | 1/20 | 0.46 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | FYN | P06241 | 1/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.46 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10428896 | 0.89 | KCNH2 (0.55) | KCNH2SSTR5NR4A2MEN1MLNR | |
| SCHEMBL9699694 | 0.86 | SSTR5 (0.54) | KCNH2SSTR5NR4A2MEN1MLNR | |
| SCHEMBL9739999 | 0.86 | SSTR5 (0.54) | KCNH2SSTR5NR4A2MEN1MLNR | |
| Water SCHEMBL10857314 | 0.83 | KCNH2 (0.51) | KCNH2SSTR5NR4A2MEN1MLNR | |
| Water SCHEMBL10857307 | 0.83 | KCNH2 (0.51) | KCNH2SSTR5NR4A2MEN1MLNR | |
| SCHEMBL9698759 | 0.83 | KCNH2 (0.51) | KCNH2SSTR5NR4A2MEN1MLNR | |
| SCHEMBL9742219 | 0.83 | SSTR5 (0.73) | KCNH2SSTR5NR4A2MEN1MLNR | |
| SCHEMBL4988156 | 0.83 | KCNH2 (0.57) | KCNH2SSTR5NR4A2MEN1MLNR | |
| SCHEMBL9535911 | 0.83 | ALDH1A1 (0.43) | KCNH2USP2LMNAGAAMAPT | |
| SCHEMBL9698698 | 0.81 | SSTR5 (0.49) | KCNH2SSTR5NR4A2MEN1MLNR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5126339-A | Antihistamine, antiserotonine | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-06-30 | — | — | US | disclosed |
| US-5025014-A | Antiallergens | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-06-18 | — | — | US | disclosed |
| US-4888426-A | CHEMICAL INTERMEDIATES | JANSSEN PHARMACEUTICA N.V. (BE) | 1989-12-19 | — | — | US | disclosed |
| US-4695569-A | ANTIALLERGENS | JANSSEN PHARMACEUTICA N.V. (BE) | 1987-09-22 | — | — | US | disclosed |