Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | TRPC4 | Q9UBN4 | 1/20 | 0.36 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9537714 | 0.87 | ALDH1A1 (0.45) | ALDH1A1KDM4EUSP2TSHRHSD17B10 | |
| SCHEMBL9535315 | 0.85 | ALDH1A1 (0.47) | ALDH1A1KDM4EUSP2TSHRHSD17B10 | |
| SCHEMBL9537470 | 0.85 | KDM4E (0.50) | ALDH1A1KDM4EUSP2TSHRHSD17B10 | |
| SCHEMBL9739638 | 0.83 | KCNH2 (0.56) | USP2MAPTGAADRD2DRD4 | |
| SCHEMBL9539854 | 0.82 | ALDH1A1 (0.52) | ALDH1A1KDM4EUSP2TSHRHSD17B10 | |
| SCHEMBL9536904 | 0.82 | RAB9A (0.50) | USP2MAPTGAASLC6A9DRD2 | |
| SCHEMBL9538853 | 0.81 | P2RX7 (0.49) | USP2DRD2DRD3LMNAKCNH2 | |
| SCHEMBL9536425 | 0.81 | KDM4E (0.43) | ALDH1A1KDM4EUSP2TSHRHSD17B10 | |
| SCHEMBL9536155 | 0.80 | USP2 (0.42) | ALDH1A1KDM4EUSP2TSHRHSD17B10 | |
| SCHEMBL9536165 | 0.80 | CCR3 (0.56) | ALDH1A1KDM4EUSP2HSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | disclosed |
| US-4839374-A | TREATING ALLERGIES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1989-06-13 | — | — | US | disclosed |
| US-4695575-A | ANTIHISTAMINES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1987-09-22 | — | — | US | disclosed |