Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | PTGES | O14684 | 4/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | APLNR | P35414 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.39 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1895299 | 0.72 | TP53 (0.78) | PARP1TP53L3MBTL1MAPK1 | |
| SCHEMBL9487922 | 0.71 | PARP1 (0.51) | PARP1TP53L3MBTL1MAPK1 | |
| SCHEMBL28308034 | 0.68 | PARP1 (0.57) | PARP1 | |
| SCHEMBL9490757 | 0.68 | KDM4E (0.50) | PARP1MAPK1HTT | |
| SCHEMBL168776 | 0.68 | PARP1 (1.00) | PARP1 | |
| SCHEMBL29900512 | 0.68 | PARP1 (1.00) | PARP1 | |
| SCHEMBL7323950 | 0.68 | PARP1 (0.56) | PARP1HTT | |
| SCHEMBL14743462 | 0.67 | ALDH1A1 (0.44) | PARP1MAPK1 | |
| SCHEMBL9126278 | 0.65 | PARP1 (0.49) | PARP1MAPK1 | |
| SCHEMBL1586541 | 0.64 | PARP1 (0.91) | PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5100897-A | Hypotensive agents, congestive heart failure, ocular hypertension | MERCK & CO., INC. (US) | 1992-03-31 | — | — | US | disclosed |
| EP-0419048-A2 | Substituted pyrimidinones as angiotensin II antagonists | MERCK & CO. INC. (US) | 1991-03-27 | — | — | EP | disclosed |