SCHEMBL9739800

SCHEMBL9739800

O=C(NC(=O)c1ccccc1Cl)Nc1ccc(Cl)c(Cl)c1

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GCGR P47871 1/20 0.65
NPC1 O15118 5/20 0.62
RAB9A P51151 4/20 0.62
POLB P06746 2/20 0.62
PKM P14618 1/20 0.62
EPHX1 P07099 2/20 0.62
EPHX2 P34913 2/20 0.62
PLCG2 P16885 1/20 0.62
TDP1 Q9NUW8 1/20 0.60
MEN1 O00255 3/20 0.59
KMT2A Q03164 3/20 0.59
MAPT P10636 3/20 0.59
ALDH1A1 P00352 2/20 0.59
KDM4E B2RXH2 1/20 0.59
NFKB1 P19838 1/20 0.59
GFER P55789 1/20 0.59
NFKB2 Q00653 1/20 0.59
RELA Q04206 1/20 0.59
SMN1; SMN2 Q16637 1/20 0.59
MAPK14 Q16539 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4254011 0.87 RAB9A (0.68) NPC1RAB9APKMTDP1MEN1
SCHEMBL9737442 0.87 EPHX1 (0.57) GCGRNPC1RAB9APOLBPKM
SCHEMBL8840342 0.86 NPC1 (0.60) GCGRNPC1RAB9APOLBPKM
SCHEMBL5442355 0.85 ALDH1A1 (0.72) NPC1RAB9APOLBMEN1KMT2A
SCHEMBL10617761 0.85 NPC1 (0.59) GCGRNPC1RAB9APOLBPKM
SCHEMBL8840248 0.85 RAB9A (0.59) GCGRNPC1RAB9APOLBPKM
Chlorbenzuron SCHEMBL5177776 0.84 GCGR (0.68) GCGRNPC1RAB9APOLBPKM
SCHEMBL9501794 0.84 MEN1 (0.73) GCGRNPC1RAB9APOLBPKM
SCHEMBL9622312 0.84 KDR (0.68) GCGRNPC1RAB9APOLBPKM
SCHEMBL8840339 0.84 TDP1 (0.59) GCGRNPC1RAB9APOLBPKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4920135-A NONPHYTOTOXIC, INTERFERE WITH METAMORPHOSIS DUPHAR INTERNATIONAL RESEARCH B.V. (NL) 1990-04-24 US claimed
US-4833151-A INTERFERES WITH METAMORPHOSES DUPHAR INTERNATIONAL RESEARCH B.V. (NL) 1989-05-23 US claimed
US-5142064-A Larvicides has benzoyl or thiobenzoyl group DUPHAR INTERNATIONAL RESEARCH B.V. (NL) 1992-08-25 US disclosed
US-4920135-A NONPHYTOTOXIC, INTERFERE WITH METAMORPHOSIS DUPHAR INTERNATIONAL RESEARCH B.V. (NL) 1990-04-24 US disclosed
US-4833151-A INTERFERES WITH METAMORPHOSES DUPHAR INTERNATIONAL RESEARCH B.V. (NL) 1989-05-23 US disclosed
US-4607044-A Insecticidal use of ureas and thioureas DUPHAR INTERNATIONAL RESEARCH B.V. (NL) 1986-08-19 US disclosed
US-4166124-A IMIDAZOLE OR PYRIMIDINE RINGS U.S. PHILIPS CORPORATION (US) 1979-08-28 US disclosed
US-4013717-A BENZOYL PHENYL UREA DERIVATIVES HAVING INSECTICIDAL ACTIVITIES U.S. PHILIPS CORPORATION (US) 1977-03-22 US disclosed
US-3989842-A Certain substituted benzoyl urea insecticides U.S. PHILIPS CORPORATION (US) 1976-11-02 US disclosed
US-3933908-A INSECTICIDE U.S. PHILIPS CORPORATION (US) 1976-01-20 US disclosed