Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 12/20 | 0.60 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.39 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.35 |
| ▸ | EDNRA | P25101 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9739893 | 0.86 | ALOX5 (0.54) | ALOX5ALOX15ALDH1A1KDM4E | |
| SCHEMBL9739966 | 0.84 | ALOX5 (0.53) | ALOX5ALOX15MCL1GPR35ALDH1A1 | |
| SCHEMBL10739817 | 0.84 | ALOX5 (0.42) | ALOX5ALOX15MCL1GPR35ALDH1A1 | |
| SCHEMBL9740227 | 0.80 | ALOX5 (0.65) | ALOX5ALOX15ALDH1A1KDM4E | |
| SCHEMBL9739801 | 0.77 | ALOX5 (0.67) | ALOX5ALOX15ALDH1A1KDM4E | |
| SCHEMBL10603436 | 0.76 | ALOX5 (0.78) | ALOX5ALOX15ALDH1A1 | |
| SCHEMBL9740342 | 0.75 | ALOX5 (1.00) | ALOX5ALOX15ALDH1A1KDM4EGLA | |
| SCHEMBL9740324 | 0.73 | ALOX5 (1.00) | ALOX5ALOX15 | |
| SCHEMBL9739648 | 0.73 | ALOX5 (0.87) | ALOX5ALOX15 | |
| SCHEMBL9739591 | 0.72 | ALOX5 (1.00) | ALOX5ALOX15PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5087638-A | Inhibitors of mammalian leukotriene biosynthesis | MERCK FROSST CANADA, INC. (CA) | 1992-02-11 | — | — | US | disclosed |
| EP-0338782-A1 | Benzofuran derivatives | MERCK FROSST CANADA INC. (CA) | 1989-10-25 | — | — | EP | disclosed |
| US-4863958-A | TREATING ALLERGIC CONDITIONS, ASTHMA, CARDIOVASCULAR DISORDERS, AND INFLAMMATION | MERCK FROSST CANADA, INC. (CA) | 1989-09-05 | — | — | US | disclosed |
| EP-0165810-B1 | BENZOFURAN AND BENZOTHIOPHENE DERIVATIVES, THEIR USE IN INHIBITING MAMMALIAN LEUKOTRIENE BIOSYNTHESIS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE DERIVATIVES | MERCK FROSST CANADA INC. (CA) | 1989-08-23 | — | — | EP | disclosed |
| EP-0200443-B1 | LIPOXYGENASE INHIBITORS | MERCK FROSST CANADA INC. (CA) | 1989-03-01 | — | — | EP | disclosed |
| US-4663347-A | ANTIINFLAMMATORY, ANTIALLERGENS, CARDIOVASCULAR | MERCK FROSST CANADA, INC. (CA) | 1987-05-05 | — | — | US | disclosed |
| EP-0200443-A1 | Lipoxygenase inhibitors | MERCK FROSST CANADA INC. (CA) | 1986-11-05 | — | — | EP | disclosed |
| EP-0165810-A2 | Benzofuran and benzothiophene derivatives, their use in inhibiting mammalian leukotriene biosynthesis, and pharmaceutical compositions containing these derivatives | MERCK FROSST CANADA INC. (CA) | 1985-12-27 | — | — | EP | disclosed |