SCHEMBL9739976

SCHEMBL9739976

Cc1nc2c(Cl)ncnc2n1C

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA2A P29274 11/20 0.40
ADORA1 P30542 10/20 0.40
ADORA2B P29275 6/20 0.40
ADORA3 P0DMS8 8/20 0.38
PI4KA P42356 2/20 0.38
PI4K2B Q8TCG2 2/20 0.38
PI4K2A Q9BTU6 2/20 0.38
PI4KB Q9UBF8 2/20 0.38
NR3C1 P04150 1/20 0.35
ALDH1A1 P00352 2/20 0.35
KDM4E B2RXH2 1/20 0.35
JAK2 O60674 1/20 0.35
LMNA P02545 1/20 0.35
HPGD P15428 1/20 0.35
HTT P42858 1/20 0.35
PAX8 Q06710 1/20 0.35
MEN1 O00255 1/20 0.33
NR2F2 P24468 1/20 0.33
KMT2A Q03164 1/20 0.33
FBP1 P09467 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9740432 0.79 ADORA2A (0.39) ADORA2AADORA1ADORA2BADORA3PI4KA
SCHEMBL15718948 0.79 PIK3CD (0.41) ADORA2AADORA1ADORA2BADORA3PI4KA
SCHEMBL31065821 0.79 ADORA2A (0.64) ADORA2AADORA1ADORA2BADORA3PI4KA
SCHEMBL788330 0.79 ADORA2A (0.64) ADORA2AADORA1ADORA2BADORA3PI4KA
SCHEMBL23436452 0.78 ADORA2A (0.47) ADORA2AADORA1ADORA2BADORA3FBP1
SCHEMBL19426740 0.78 ADORA3 (0.47) ADORA2AADORA1ADORA2BADORA3PI4KA
SCHEMBL4402912 0.77 ADORA2A (0.66) ADORA2AADORA1ADORA2BADORA3PI4KA
SCHEMBL15719155 0.77 ADORA2A (0.45) ADORA2AADORA1ADORA2BADORA3MEN1
SCHEMBL15718693 0.77 CSNK2A2 (0.39) ADORA2AADORA1ADORA2BADORA3PI4KA
SCHEMBL783764 0.76 ADORA3 (0.68) ADORA2AADORA1ADORA2BADORA3PI4KA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5126339-A Antihistamine, antiserotonine JANSSEN PHARMACEUTICA N.V. (BE) 1992-06-30 US disclosed
US-5025014-A Antiallergens JANSSEN PHARMACEUTICA N.V. (BE) 1991-06-18 US disclosed
US-4888426-A CHEMICAL INTERMEDIATES JANSSEN PHARMACEUTICA N.V. (BE) 1989-12-19 US disclosed
US-4839374-A TREATING ALLERGIES JANSSEN PHARMACEUTICA, N.V. (BE) 1989-06-13 US disclosed
US-4695569-A ANTIALLERGENS JANSSEN PHARMACEUTICA N.V. (BE) 1987-09-22 US disclosed
US-4695575-A ANTIHISTAMINES JANSSEN PHARMACEUTICA, N.V. (BE) 1987-09-22 US disclosed
EP-0151826-A1 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines JANSSEN PHARMACEUTICA N.V. (BE) 1985-08-21 EP disclosed
EP-0144101-A2 Bicyclic heterocyclyl containing N-(bicyclic heterocyclyl)-4-piperidinamines JANSSEN PHARMACEUTICA N.V. (BE) 1985-06-12 EP disclosed