SCHEMBL9740432

SCHEMBL9740432

Cn1c(O)nc2c(Cl)ncnc21

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA2A P29274 7/20 0.39
ADORA1 P30542 7/20 0.39
ADORA2B P29275 4/20 0.39
FDPS P14324 1/20 0.35
ADORA3 P0DMS8 5/20 0.34
PI4KA P42356 2/20 0.34
PI4K2B Q8TCG2 2/20 0.34
PI4K2A Q9BTU6 2/20 0.34
PI4KB Q9UBF8 2/20 0.34
FGFR1 P11362 4/20 0.34
FGFR4 P22455 4/20 0.34
P2RX7 Q99572 2/20 0.33
FBP1 P09467 1/20 0.32
DGAT1 O75907 1/20 0.32
ALDH1A1 P00352 2/20 0.32
MAPT P10636 1/20 0.32
HDAC6 Q9UBN7 1/20 0.31
KDM4E B2RXH2 1/20 0.31
JAK2 O60674 1/20 0.31
LMNA P02545 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL788248 0.80 ALDH1A1 (0.38) ADORA2AADORA1ADORA2BFDPSADORA3
SCHEMBL9739976 0.79 ADORA2A (0.40) ADORA2AADORA1ADORA2BFDPSADORA3
SCHEMBL15718948 0.78 PIK3CD (0.41) ADORA2AADORA1ADORA2BFDPSADORA3
SCHEMBL2980005 0.78 ADORA2A (0.64) ADORA2AADORA1ADORA2BADORA3PI4KA
SCHEMBL788330 0.78 ADORA2A (0.64) ADORA2AADORA1ADORA2BADORA3PI4KA
SCHEMBL31065821 0.78 ADORA2A (0.64) ADORA2AADORA1ADORA2BADORA3PI4KA
SCHEMBL4067321 0.76 ADORA3 (0.57) ADORA2AADORA1ADORA2BADORA3PI4KA
SCHEMBL15718693 0.75 CSNK2A2 (0.39) ADORA2AADORA1ADORA2BFDPSADORA3
SCHEMBL788659 0.74 PIK3CD (0.42) ADORA2AADORA1ADORA2BFDPSADORA3
SCHEMBL19426740 0.73 ADORA3 (0.47) ADORA2AADORA1ADORA2BADORA3PI4KA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5126339-A Antihistamine, antiserotonine JANSSEN PHARMACEUTICA N.V. (BE) 1992-06-30 US disclosed
US-5025014-A Antiallergens JANSSEN PHARMACEUTICA N.V. (BE) 1991-06-18 US disclosed
US-4888426-A CHEMICAL INTERMEDIATES JANSSEN PHARMACEUTICA N.V. (BE) 1989-12-19 US disclosed
US-4839374-A TREATING ALLERGIES JANSSEN PHARMACEUTICA, N.V. (BE) 1989-06-13 US disclosed
US-4695569-A ANTIALLERGENS JANSSEN PHARMACEUTICA N.V. (BE) 1987-09-22 US disclosed
US-4695575-A ANTIHISTAMINES JANSSEN PHARMACEUTICA, N.V. (BE) 1987-09-22 US disclosed
EP-0151826-A1 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines JANSSEN PHARMACEUTICA N.V. (BE) 1985-08-21 EP disclosed
EP-0144101-A2 Bicyclic heterocyclyl containing N-(bicyclic heterocyclyl)-4-piperidinamines JANSSEN PHARMACEUTICA N.V. (BE) 1985-06-12 EP disclosed