Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | EBP | Q15125 | 2/20 | 0.50 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.50 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11073388 | 0.88 | GAA (0.51) | HTR1ASLC6A4SIGMAR1MEN1KMT2A | |
| SCHEMBL6769203 | 0.88 | SIGMAR1 (0.50) | HTR1ASLC6A4SIGMAR1MEN1KMT2A | |
| SCHEMBL7815093 | 0.88 | MAPT (0.58) | HTR1ASLC6A4SIGMAR1MEN1KMT2A | |
| SCHEMBL11076598 | 0.88 | MAPT (0.58) | HTR1ASLC6A4SIGMAR1MEN1KMT2A | |
| SCHEMBL11075907 | 0.88 | MAPT (0.58) | HTR1ASLC6A4SIGMAR1MEN1KMT2A | |
| SCHEMBL7809212 | 0.88 | GAA (0.51) | HTR1ASLC6A4SIGMAR1MEN1KMT2A | |
| SCHEMBL11071315 | 0.88 | GAA (0.51) | HTR1ASLC6A4SIGMAR1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL11079512 | 0.87 | GAA (0.52) | HTR1ASLC6A4SIGMAR1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL11076058 | 0.87 | MAPT (0.57) | HTR1ASLC6A4SIGMAR1MEN1KMT2A | |
| SCHEMBL9208591 | 0.84 | SIGMAR1 (0.52) | HTR1ASLC6A4SIGMAR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5175157-A | Cardiovascular disorders | BOEHRINGER INGELHEIM GMBH (DE) | 1992-12-29 | — | — | US | disclosed |
| EP-0224794-B1 | CYCLIC AMINE DERIVATIVES, MEDICINES CONTAINING THESE COMPOUNDS AND PROCESS FOR THEIR PREPARATION | Dr. Karl Thomae GmbH (DE) | 1990-09-12 | — | — | EP | disclosed |
| EP-0224794-A2 | Cyclic amine derivatives, medicines containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1987-06-10 | — | — | EP | disclosed |