Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 15/20 | 0.48 |
| ▸ | APP | P05067 | 1/20 | 0.47 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.47 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.47 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.47 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.47 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.47 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.47 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9740006 | 1.00 | REN (0.48) | RENAPPPSEN1PSEN2APH1B | |
| SCHEMBL9740000 | 1.00 | REN (0.48) | RENAPPPSEN1PSEN2APH1B | |
| SCHEMBL9849618 | 1.00 | REN (0.48) | RENAPPPSEN1PSEN2APH1B | |
| SCHEMBL9740589 | 0.90 | REN (0.54) | REN | |
| SCHEMBL9740591 | 0.90 | REN (0.54) | REN | |
| SCHEMBL9741066 | 0.88 | BIRC2 (0.47) | RENBIRC2 | |
| SCHEMBL9741072 | 0.88 | BIRC2 (0.47) | RENBIRC2 | |
| SCHEMBL9740083 | 0.88 | REN (0.44) | REN | |
| SCHEMBL9740085 | 0.88 | REN (0.44) | REN | |
| SCHEMBL9849432 | 0.87 | REN (0.36) | RENAPPPSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5104869-A | Renin inhibitors | AMERICAN CYANAMID COMPANY (US) | 1992-04-14 | — | — | US | disclosed |
| EP-0427939-A2 | Renin inhibitors | AMERICAN CYANAMID COMPANY (US) | 1991-05-22 | — | — | EP | disclosed |