Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK3 | Q9Y572 | 2/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.33 |
| ▸ | PRKACA | P17612 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | FYN | P06241 | 1/20 | 0.31 |
| ▸ | CASP3 | P42574 | 1/20 | 0.31 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.31 |
| ▸ | AHR | P35869 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.30 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL161183 | 0.82 | ABCG2 (0.39) | ALDH1A1HSD17B10CYP3A4 | |
| SCHEMBL8638641 | 0.80 | MAPT (0.39) | MAPTLMNAGAAKDM4EALDH1A1 | |
| SCHEMBL9738660 | 0.77 | KDM4E (0.41) | ROCK1PRKACAMAPTLMNAKDM4E | |
| SCHEMBL6784931 | 0.75 | HSP90AA1 (0.30) | — | |
| SCHEMBL6210971 | 0.70 | PDE4A (0.41) | MAPTLMNAALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL4347210 | 0.69 | RIPK3 (0.56) | RIPK3ROCK1MAPTALDH1A1DYRK1A | |
| SCHEMBL3404505 | 0.69 | ABCG2 (0.37) | ALDH1A1HSD17B10CYP3A4 | |
| SCHEMBL83574 | 0.67 | NQO2 (0.40) | LMNAGAAALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL6904035 | 0.67 | ABCG2 (0.36) | ALDH1A1HSD17B10 | |
| SCHEMBL6216565 | 0.66 | ITGB2 (0.39) | MAPTLMNAGAAKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5134150-A | Administering diaryl-substituted imidazothiazoles; antiarthritic agents | SMITHKLINE BEECHAM CORPORATION (US) | 1992-07-28 | — | — | US | disclosed |