Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | PTPRC | P08575 | 1/20 | 0.39 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15377351 | 0.92 | ALOX5 (0.45) | KDM4ELMNACA12CA2CA9 | |
| SCHEMBL161183 | 0.82 | ABCG2 (0.39) | ALDH1A1HSD17B10TDP1CYP3A4GSK3B | |
| SCHEMBL8638641 | 0.80 | MAPT (0.39) | KDM4ELMNAALDH1A1HSD17B10PTGS2 | |
| SCHEMBL8212957 | 0.79 | ABCG2 (0.40) | KDM4EPTGS2SMN1; SMN2NPC1MAPT | |
| SCHEMBL6210971 | 0.79 | PDE4A (0.41) | LMNAALDH1A1CYP3A4NPC1MAPT | |
| SCHEMBL6784931 | 0.79 | HSP90AA1 (0.30) | — | |
| SCHEMBL11709917 | 0.78 | KDM4E (0.42) | KDM4ELMNACA12CA2CA9 | |
| SCHEMBL9740282 | 0.77 | RIPK3 (0.37) | KDM4ELMNAALDH1A1HSD17B10CYP3A4 | |
| SCHEMBL4009084 | 0.75 | NPC1 (0.47) | KDM4ELMNAALDH1A1HSD17B10PTGS2 | |
| SCHEMBL11571390 | 0.75 | PREP (0.43) | LMNAALDH1A1HSD17B10PTGS2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5134150-A | Administering diaryl-substituted imidazothiazoles; antiarthritic agents | SMITHKLINE BEECHAM CORPORATION (US) | 1992-07-28 | — | — | US | disclosed |