Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 20/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1123037 | 1.00 | CA2 (1.00) | CA2 | |
| SCHEMBL9740319 | 1.00 | CA2 (1.00) | CA2 | |
| Hydrochloric Acid SCHEMBL10512111 | 0.98 | CA2 (1.00) | CA2 | |
| SCHEMBL10514253 | 0.85 | CA2 (0.74) | CA2 | |
| SCHEMBL10513374 | 0.84 | CA2 (1.00) | CA2 | |
| SCHEMBL1804003 | 0.84 | CA2 (1.00) | CA2 | |
| SCHEMBL10795922 | 0.84 | CA2 (1.00) | CA2 | |
| SCHEMBL10512797 | 0.80 | CA2 (0.69) | CA2 | |
| SCHEMBL10800026 | 0.80 | CA2 (0.67) | CA2 | |
| Hydrochloric Acid SCHEMBL10514436 | 0.79 | CA2 (0.76) | CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0189690-B1 | SUBSTITUTED AROMATIC SULFONAMIDES, THEIR PREPARATION AND OPHTHALMIC COMPOSITIONS CONTAINING THEM | MERCK & CO. INC. (US) | 1989-03-01 | — | — | EP | claimed |
| US-4677115-A | Antiglaucoma thieno-thiopyran and thieno-thiepin sulfonamide derivatives, compositions, and method of use thereof | MERCK & CO., INC. (US) | 1987-06-30 | — | — | US | claimed |
| EP-0189690-A1 | Substituted aromatic sulfonamides, their preparation and ophthalmic compositions containing them | MERCK & CO. INC. (US) | 1986-08-06 | — | — | EP | claimed |
| US-5157129-A | Carbonic anhydrase inhibitor, treatment of ocular hypertension and glaucoma | MERCK & CO., INC. (US) | 1992-10-20 | — | — | US | disclosed |
| EP-0453288-A1 | Enantiospecific synthesis of S(+)-5,6-dihydro-4-(R-amino)-4H thieno (2,3-B)thiopyran-2-sulfonamide-7,7-dioxide | MERCK & CO. INC. (US) | 1991-10-23 | — | — | EP | disclosed |
| EP-0189690-B1 | SUBSTITUTED AROMATIC SULFONAMIDES, THEIR PREPARATION AND OPHTHALMIC COMPOSITIONS CONTAINING THEM | MERCK & CO. INC. (US) | 1989-03-01 | — | — | EP | disclosed |
| US-4677115-A | Antiglaucoma thieno-thiopyran and thieno-thiepin sulfonamide derivatives, compositions, and method of use thereof | MERCK & CO., INC. (US) | 1987-06-30 | — | — | US | disclosed |
| EP-0189690-A1 | Substituted aromatic sulfonamides, their preparation and ophthalmic compositions containing them | MERCK & CO. INC. (US) | 1986-08-06 | — | — | EP | disclosed |