Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | GLRA3 | O75311 | 1/20 | 0.41 |
| ▸ | GLRB | P48167 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | BLM | P54132 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9246935 | 0.81 | AKR1C2 (0.58) | GLRA3GLRBSMN1; SMN2CYP2C9CYP2C19 | |
| SCHEMBL47579 | 0.75 | CA2 (0.64) | LMNARECQLGLRA3GLRBSMN1; SMN2 | |
| SCHEMBL4879678 | 0.74 | CA2 (0.50) | LMNARECQLGLRA3GLRBSMN1; SMN2 | |
| SCHEMBL30855203 | 0.74 | ERN1 (0.46) | LMNARECQLALDH1A1MEN1KMT2A | |
| SCHEMBL29334185 | 0.74 | ERN1 (0.46) | LMNARECQLALDH1A1MEN1KMT2A | |
| SCHEMBL9740619 | 0.73 | AKR1C2 (0.47) | LMNASMN1; SMN2CYP2C19ALDH1A1MEN1 | |
| SCHEMBL28836082 | 0.73 | BCL2 (0.47) | SMN1; SMN2CYP2C9TP53ALDH1A1MEN1 | |
| SCHEMBL9740814 | 0.72 | ALDH1A1 (0.47) | LMNARECQLCYP2C9HIF1ACYP1A2 | |
| SCHEMBL11722271 | 0.72 | HSPA5 (0.47) | LMNAGLRA3GLRBSMN1; SMN2CYP2C9 | |
| SCHEMBL1170584 | 0.72 | HSPA5 (0.53) | LMNARECQLGLRA3GLRBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5087638-A | Inhibitors of mammalian leukotriene biosynthesis | MERCK FROSST CANADA, INC. (CA) | 1992-02-11 | — | — | US | disclosed |
| EP-0338782-A1 | Benzofuran derivatives | MERCK FROSST CANADA INC. (CA) | 1989-10-25 | — | — | EP | disclosed |
| US-4863958-A | TREATING ALLERGIC CONDITIONS, ASTHMA, CARDIOVASCULAR DISORDERS, AND INFLAMMATION | MERCK FROSST CANADA, INC. (CA) | 1989-09-05 | — | — | US | disclosed |