Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 1/20 | 0.56 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.56 |
| ▸ | IDO1 | P14902 | 1/20 | 0.47 |
| ▸ | EP300 | Q09472 | 1/20 | 0.46 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.46 |
| ▸ | NQO1 | P15559 | 1/20 | 0.41 |
| ▸ | PLK1 | P53350 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | HPGDS | O60760 | 1/20 | 0.38 |
| ▸ | CDC25B | P30305 | 2/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA4 | P22748 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.37 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6932331 | 0.79 | AR (0.51) | IMPDH2IMPDH1MAPTCA12CA1 | |
| SCHEMBL6621338 | 0.78 | KDM4E (0.45) | MAPTLMNAARHPGDKMT2A | |
| SCHEMBL15521630 | 0.77 | IDO1 (0.53) | IMPDH2IMPDH1IDO1EP300KAT8 | |
| SCHEMBL29380721 | 0.76 | IDO1 (0.73) | IMPDH2IMPDH1IDO1EP300KAT8 | |
| SCHEMBL419307 | 0.76 | IDO1 (0.73) | IMPDH2IMPDH1IDO1EP300KAT8 | |
| SCHEMBL11986361 | 0.74 | IDO1 (0.50) | IMPDH2IMPDH1IDO1EP300KAT8 | |
| SCHEMBL17042693 | 0.73 | IMPDH2 (0.63) | IMPDH2IMPDH1IDO1EP300KAT8 | |
| SCHEMBL29664146 | 0.73 | IMPDH2 (0.63) | IMPDH2IMPDH1IDO1EP300KAT8 | |
| SCHEMBL9711216 | 0.72 | MAPT (0.53) | IMPDH2IMPDH1NQO1MAPTHPGD | |
| SCHEMBL6624088 | 0.72 | IDO1 (0.52) | IDO1EP300KAT8MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5153227-A | Treatment of diabetes and galactosemia complications | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-10-06 | — | — | US | disclosed |