Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHCR7 | Q9UBM7 | 1/20 | 0.51 |
| ▸ | HTR1A | P08908 | 2/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HCN4 | Q9Y3Q4 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9740763 | 0.95 | MEN1 (0.53) | DHCR7SIGMAR1MAPTHCN4MEN1 | |
| Hydrochloric Acid SCHEMBL9740787 | 0.94 | MEN1 (0.52) | DHCR7SIGMAR1MAPTHCN4MEN1 | |
| SCHEMBL10720589 | 0.91 | BCHE (0.47) | DHCR7HTR1ASLC6A4MAPTHCN4 | |
| SCHEMBL9739547 | 0.90 | ABCB1 (0.53) | HTR1ASLC6A4MAPTHCN4CYP3A4 | |
| SCHEMBL9739280 | 0.89 | HCN4 (0.59) | DHCR7HTR1ASLC6A4MAPTHCN4 | |
| SCHEMBL9739687 | 0.86 | HCN4 (0.45) | DHCR7HTR1ASLC6A4MAPTHCN4 | |
| SCHEMBL9740561 | 0.85 | CHRNB2 (0.49) | SIGMAR1MAPTHCN4MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL9739300 | 0.85 | CYP3A4 (0.46) | MAPTHCN4MEN1KMT2ACYP3A4 | |
| SCHEMBL9746442 | 0.85 | CHRNB2 (0.46) | SIGMAR1MAPTHCN4CYP3A4ALOX15 | |
| SCHEMBL9739498 | 0.85 | ABCB1 (0.51) | MAPTHCN4MEN1KMT2ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5175157-A | Cardiovascular disorders | BOEHRINGER INGELHEIM GMBH (DE) | 1992-12-29 | — | — | US | disclosed |
| EP-0224794-B1 | CYCLIC AMINE DERIVATIVES, MEDICINES CONTAINING THESE COMPOUNDS AND PROCESS FOR THEIR PREPARATION | Dr. Karl Thomae GmbH (DE) | 1990-09-12 | — | — | EP | disclosed |
| EP-0224794-A2 | Cyclic amine derivatives, medicines containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1987-06-10 | — | — | EP | disclosed |