Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | ACHE | P22303 | 2/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | GLA | P06280 | 2/20 | 0.41 |
| ▸ | CASP1 | P29466 | 2/20 | 0.41 |
| ▸ | CASP7 | P55210 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | BLM | P54132 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5498694 | 0.87 | KDM4E (0.50) | KDM4EHSD17B10NPC1RAB9AACHE | |
| SCHEMBL916641 | 0.78 | EDNRA (0.46) | KDM4EHSD17B10NPC1RAB9AALDH1A1 | |
| SCHEMBL11876962 | 0.77 | PTPN1 (0.47) | KDM4EHSD17B10NPC1RAB9APTPN1 | |
| SCHEMBL28731706 | 0.76 | KDM4E (0.41) | KDM4EHSD17B10NPC1RAB9AACHE | |
| SCHEMBL31493902 | 0.76 | KDM4E (0.41) | KDM4EHSD17B10NPC1RAB9AACHE | |
| SCHEMBL13349007 | 0.76 | KDM4E (0.44) | KDM4ENPC1RAB9AALDH1A1CASP1 | |
| SCHEMBL25029608 | 0.75 | HTR2C (0.43) | KDM4EHSD17B10NPC1RAB9AACHE | |
| SCHEMBL13349093 | 0.74 | ALDH1A1 (0.43) | KDM4EHSD17B10MAPK1ALDH1A1MAPT | |
| SCHEMBL30179347 | 0.73 | PTGS2 (0.59) | KDM4EHSD17B10ACHEPTPN1MAPK1 | |
| SCHEMBL172737 | 0.73 | PTGS2 (0.59) | KDM4EHSD17B10ACHEPTPN1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5087638-A | Inhibitors of mammalian leukotriene biosynthesis | MERCK FROSST CANADA, INC. (CA) | 1992-02-11 | — | — | US | disclosed |
| EP-0338782-A1 | Benzofuran derivatives | MERCK FROSST CANADA INC. (CA) | 1989-10-25 | — | — | EP | disclosed |
| US-4863958-A | TREATING ALLERGIC CONDITIONS, ASTHMA, CARDIOVASCULAR DISORDERS, AND INFLAMMATION | MERCK FROSST CANADA, INC. (CA) | 1989-09-05 | — | — | US | disclosed |
| EP-0165810-B1 | BENZOFURAN AND BENZOTHIOPHENE DERIVATIVES, THEIR USE IN INHIBITING MAMMALIAN LEUKOTRIENE BIOSYNTHESIS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE DERIVATIVES | MERCK FROSST CANADA INC. (CA) | 1989-08-23 | — | — | EP | disclosed |
| EP-0165810-A2 | Benzofuran and benzothiophene derivatives, their use in inhibiting mammalian leukotriene biosynthesis, and pharmaceutical compositions containing these derivatives | MERCK FROSST CANADA INC. (CA) | 1985-12-27 | — | — | EP | disclosed |