SCHEMBL9740639

CC(=O)NCc1ccccc1-c1ccc(CN2C(=O)[C@H](NC(=O)CC(C)(C)N)CCc3ccccc32)cc1.CC(=O)NCc1ccccc1-c1ccc(CN2C(=O)[C@H](NC(=O)CC(C)(C)NC[C@@H](C)O)CCc3ccccc32)cc1.CC(C)(N)CC(=O)N[C@@H]1CCc2ccccc2N(Cc2ccc(-c3ccccc3CNC(=O)c3ccccc3)cc2)C1=O

nearest known ligand 0.64

Predicted protein targets (top 4)

	gene	UniProt	supporting neighbours	confidence
▸	GHSR	Q92847	4/20	0.57

▸	AGTR1	P30556	1/20	0.56

▸	XIAP	P98170	12/20	0.47

▸	NPY1R	P25929	1/20	0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL9024928	0.94	GHSR (0.60)	GHSRAGTR1XIAPNPY1R
SCHEMBL9024855	0.93	GHSR (0.62)	GHSRAGTR1XIAP
SCHEMBL9024490	0.90	GHSR (0.69)	GHSRAGTR1XIAPNPY1R
SCHEMBL7791590	0.88	GHSR (0.63)	GHSRAGTR1XIAP
SCHEMBL9024983	0.88	GHSR (0.72)	GHSRAGTR1XIAPNPY1R
SCHEMBL9742779	0.86	GHSR (0.60)	GHSRAGTR1XIAP
SCHEMBL8329751	0.86	GHSR (0.60)	GHSRAGTR1XIAP
SCHEMBL7795991	0.86	GHSR (0.72)	GHSRAGTR1XIAPNPY1R
SCHEMBL7786018	0.85	GHSR (0.72)	GHSRAGTR1XIAPNPY1R
SCHEMBL7791806	0.85	GHSR (0.74)	GHSRAGTR1XIAPNPY1R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-1992016524-A1	BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE	MERCK & CO., INC. (US)	1992-10-01	—	—	WO	claimed