Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BLM | P54132 | 2/20 | 0.78 |
| ▸ | MEN1 | O00255 | 2/20 | 0.78 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.78 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.78 |
| ▸ | LMNA | P02545 | 1/20 | 0.78 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.78 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.78 |
| ▸ | VCP | P55072 | 1/20 | 0.78 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.78 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.78 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.65 |
| ▸ | PNP | P00491 | 6/20 | 0.58 |
| ▸ | HBB | P68871 | 2/20 | 0.58 |
| ▸ | USP2 | O75604 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | EDNRA | P25101 | 1/20 | 0.58 |
| ▸ | HTR2A | P28223 | 1/20 | 0.58 |
| ▸ | RECQL | P46063 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | HPRT1 | P00492 | 7/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9740338 | 0.99 | BLM (0.77) | BLMMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL10595461 | 0.90 | BLM (0.68) | BLMMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL9742931 | 0.89 | BLM (0.74) | BLMMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL9741506 | 0.88 | BLM (0.72) | BLMMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL9661300 | 0.88 | BLM (0.72) | BLMMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL9748486 | 0.88 | BLM (0.72) | BLMMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL12626658 | 0.88 | BLM (0.87) | BLMMEN1KMT2AALDH1A1LMNA | |
| Ganciclovir SCHEMBL27842151 | 0.88 | BLM (0.95) | BLMMEN1KMT2AALDH1A1LMNA | |
| Ganciclovir SCHEMBL3033 | 0.88 | BLM (1.00) | BLMMEN1KMT2AALDH1A1LMNA | |
| Ganciclovir SCHEMBL2160505 | 0.88 | BLM (1.00) | BLMMEN1KMT2AALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5098906-A | Purine derivatives | WARNER-LAMBERT COMPANY (US) | 1992-03-24 | — | — | US | disclosed |
| US-4921859-A | Purine derivatives | WARNER-LAMBERT COMPANY (US) | 1990-05-01 | — | — | US | disclosed |
| US-4918219-A | Glycerine derivatives | WARNER-LAMBERT COMPANY (US) | 1990-04-17 | — | — | US | disclosed |
| US-4806642-A | Purine derivatives | WARNER-LAMBERT COMPANY (US) | 1989-02-21 | — | — | US | disclosed |
| EP-0145207-B1 | PURINE DERIVATIVES | WARNER-LAMBERT COMPANY (US) | 1989-01-25 | — | — | EP | disclosed |
| EP-0145207-A1 | Purine derivatives | WARNER-LAMBERT COMPANY (US) | 1985-06-19 | — | — | EP | disclosed |