Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Salicylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.55 |
| ▸ | HPGD | P15428 | 7/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | CA12 | O43570 | 1/20 | 0.55 |
| ▸ | CA1 | P00915 | 1/20 | 0.55 |
| ▸ | CA2 | P00918 | 1/20 | 0.55 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.55 |
| ▸ | CA4 | P22748 | 1/20 | 0.55 |
| ▸ | CA6 | P23280 | 1/20 | 0.55 |
| ▸ | CA7 | P43166 | 1/20 | 0.55 |
| ▸ | CA9 | Q16790 | 1/20 | 0.55 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.55 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | G6PD | P11413 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Salicylic Acid SCHEMBL9741275 | 1.00 | ALDH1A1 (0.55) | ALDH1A1KDM4EHPGDSMN1; SMN2CA12 | |
| Salicylic Acid SCHEMBL9740951 | 1.00 | ALDH1A1 (0.55) | ALDH1A1KDM4EHPGDSMN1; SMN2CA12 | |
| SCHEMBL6478149 | 0.85 | HCAR2 (0.58) | ALDH1A1KDM4ESMN1; SMN2HSD17B10LMNA | |
| SCHEMBL27820414 | 0.85 | HCAR2 (0.58) | ALDH1A1KDM4ESMN1; SMN2HSD17B10LMNA | |
| SCHEMBL5956415 | 0.85 | HCAR2 (0.58) | ALDH1A1KDM4ESMN1; SMN2HSD17B10LMNA | |
| SCHEMBL264866 | 0.85 | HCAR2 (0.58) | ALDH1A1KDM4ESMN1; SMN2HSD17B10LMNA | |
| Methane SCHEMBL10711774 | 0.84 | HCAR2 (0.56) | ALDH1A1KDM4ESMN1; SMN2HSD17B10LMNA | |
| Hydrochloric Acid SCHEMBL27791121 | 0.84 | HCAR2 (0.56) | ALDH1A1KDM4ESMN1; SMN2HSD17B10LMNA | |
| Hydrogen Sulfide SCHEMBL27486651 | 0.84 | HCAR2 (0.56) | ALDH1A1KDM4ESMN1; SMN2HSD17B10LMNA | |
| SCHEMBL112399 | 0.81 | LMNA (0.55) | ALDH1A1KDM4EHPGDSMN1; SMN2CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5081117-A | Treatment of memory dysfunctions such as in Alzheimer's disease | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-01-14 | — | — | US | claimed |