Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | CASP4 | P49662 | 1/20 | 0.47 |
| ▸ | CASP5 | P51878 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | CTSB | P07858 | 1/20 | 0.43 |
| ▸ | CTSS | P25774 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | IDH2 | P48735 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11811366 | 0.89 | KMT2A (0.51) | HRH1TDP1USP2SMN1; SMN2POLB | |
| SCHEMBL11564141 | 0.83 | MAPK1 (0.54) | TDP1USP2SMN1; SMN2KMT2AMAPK1 | |
| SCHEMBL24325504 | 0.76 | HRH1 (0.61) | HRH1TDP1USP2SMN1; SMN2POLB | |
| SCHEMBL14505381 | 0.75 | HRH1 (0.59) | HRH1TDP1USP2SMN1; SMN2POLB | |
| SCHEMBL777905 | 0.74 | USP2 (0.72) | HRH1TDP1USP2SMN1; SMN2POLB | |
| SCHEMBL10774254 | 0.74 | POLB (0.50) | HRH1TDP1USP2SMN1; SMN2POLB | |
| SCHEMBL10774260 | 0.74 | POLB (0.50) | HRH1TDP1USP2SMN1; SMN2POLB | |
| SCHEMBL11019082 | 0.73 | PDE10A (0.39) | HRH1TDP1ALDH1A1KDM4EGAA | |
| SCHEMBL10963751 | 0.73 | PDE10A (0.48) | HRH1TDP1USP2SMN1; SMN2CASP1 | |
| SCHEMBL1229731 | 0.73 | HRH1 (0.85) | HRH1TDP1USP2SMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992018478-A1 | HETEROCYCLIC AMINES USEFUL IN THE THERAPY OF ASTHMA AND INFLAMMATION OF THE RESPIRATORY TRACT | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1992-10-29 | — | — | WO | disclosed |