Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 2/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.34 |
| ▸ | CCND1 | P24385 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | CCND3 | P30281 | 1/20 | 0.34 |
| ▸ | CDK7 | P50613 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11015949 | 0.83 | MAPK1 (0.39) | PDE10AGAATDP1PDE4APDE4B | |
| SCHEMBL9741920 | 0.73 | HRH1 (0.55) | GAATDP1HRH1KDM4EALDH1A1 | |
| SCHEMBL15741416 | 0.71 | HTR1A (0.49) | PDE10A | |
| Hydrochloric Acid SCHEMBL976407 | 0.70 | HTR1A (0.48) | PDE10A | |
| Hydrochloric Acid SCHEMBL15741315 | 0.70 | HTR1A (0.48) | PDE10A | |
| SCHEMBL11018122 | 0.69 | MAPK1 (0.39) | PDE10AGAATDP1HRH4HRH1 | |
| SCHEMBL11828795 | 0.67 | PDE4A (0.41) | PDE10ATDP1CHRNB2CHRNA4PDE4A | |
| SCHEMBL15286212 | 0.67 | ALDH1A1 (0.48) | PDE10AGAATDP1KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL980045 | 0.67 | PDE10A (0.40) | PDE10AKDM4EALDH1A1 | |
| SCHEMBL4311864 | 0.66 | PDE10A (0.51) | PDE10ACHRNB2CHRNA4HRH4PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0063509-B1 | 2-PIPERAZINO-PYRIMIDINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION, MEDICAMENTS CONTAINING THEM AND THEIR USE AS INTERMEDIATES IN THE MANUFACTURE OF MEDICAMENTS | PHARMUKA LABORATOIRES (FR) | 1985-02-20 | — | — | EP | claimed |
| EP-0063509-B1 | 2-PIPERAZINO-PYRIMIDINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION, MEDICAMENTS CONTAINING THEM AND THEIR USE AS INTERMEDIATES IN THE MANUFACTURE OF MEDICAMENTS | PHARMUKA LABORATOIRES (FR) | 1985-02-20 | — | — | EP | disclosed |
| EP-0063509-A1 | 2-Piperazino-pyrimidine derivatives, processes for their preparation, medicaments containing them and their use as intermediates in the manufacture of medicaments | PHARMUKA LABORATOIRES (FR) | 1982-10-27 | — | — | EP | disclosed |