Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.55 |
| ▸ | RAB9A | P51151 | 5/20 | 0.55 |
| ▸ | HPGD | P15428 | 3/20 | 0.55 |
| ▸ | DPP4 | P27487 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.43 |
| ▸ | TEAD3 | Q99594 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.43 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.43 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10914597 | 0.82 | NPC1 (0.65) | NPC1RAB9AHPGDDPP4SMN1; SMN2 | |
| SCHEMBL9742488 | 0.82 | NPC1 (0.65) | NPC1RAB9AHPGDDPP4SMN1; SMN2 | |
| SCHEMBL10509504 | 0.80 | NPC1 (0.55) | NPC1RAB9AHPGDDPP4SMN1; SMN2 | |
| SCHEMBL10509497 | 0.80 | NPC1 (0.55) | NPC1RAB9AHPGDDPP4SMN1; SMN2 | |
| SCHEMBL10756387 | 0.79 | LTA4H (0.56) | NPC1RAB9AHPGDDPP4SMN1; SMN2 | |
| SCHEMBL10507283 | 0.77 | NPC1 (0.62) | NPC1RAB9ADPP4SMN1; SMN2MAPT | |
| SCHEMBL10507275 | 0.77 | NPC1 (0.62) | NPC1RAB9ADPP4SMN1; SMN2MAPT | |
| SCHEMBL19658205 | 0.77 | SPHK1 (0.38) | — | |
| SCHEMBL10509401 | 0.76 | MEN1 (0.57) | NPC1RAB9ADPP4 | |
| SCHEMBL10509400 | 0.76 | MEN1 (0.57) | NPC1RAB9ADPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0201742-B1 | N-ACYLPYRROLIDINE DERIVATIVES, PROCESSES FOR PREPARING THEM, PHARMACEUTICAL COMPOSITION AND USE | SUNTORY LIMITED (JP) | 1992-12-30 | — | — | EP | disclosed |
| US-5086055-A | Treating asthma, rhinitis, atopic dermatitis, chronic hives and conjunctivitis | A. H. ROBINS COMPANY, INCORPORATED (US) | 1992-02-04 | — | — | US | disclosed |
| US-4701465-A | ANTI-AMNESIC AGENTS | SUNTORY LIMITED (JP) | 1987-10-20 | — | — | US | disclosed |
| EP-0201742-A2 | N-Acylpyrrolidine derivatives, processes for preparing them, pharmaceutical composition and use | SUNTORY LIMITED (JP) | 1986-11-20 | — | — | EP | disclosed |