Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPR3 | P17342 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 3/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.37 |
| ▸ | MMP2 | P08253 | 5/20 | 0.36 |
| ▸ | MMP1 | P03956 | 4/20 | 0.36 |
| ▸ | MMP3 | P08254 | 4/20 | 0.36 |
| ▸ | MMP7 | P09237 | 4/20 | 0.36 |
| ▸ | MMP13 | P45452 | 4/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | CTSS | P25774 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9744960 | 1.00 | NPR3 (0.41) | NPR3CA12CA14GAAEPHX1 | |
| SCHEMBL12658457 | 0.76 | AAK1 (0.47) | CA12CA14GAAEPHX1BTK | |
| SCHEMBL27338949 | 0.75 | GAA (0.38) | NPR3CA12CA14GAAEPHX1 | |
| SCHEMBL2810319 | 0.75 | NPR3 (0.39) | NPR3GAAEPHX1MMP2MMP1 | |
| SCHEMBL27799064 | 0.74 | GAA (0.40) | NPR3GAAEPHX1BTKCTSS | |
| SCHEMBL1634930 | 0.74 | GAA (0.40) | NPR3GAAEPHX1BTKCTSS | |
| SCHEMBL5267768 | 0.74 | EPHX1 (0.44) | NPR3CA12CA14GAAEPHX1 | |
| SCHEMBL23005710 | 0.74 | CTSS (0.47) | GAAEPHX1MMP2MMP1MMP3 | |
| SCHEMBL22125910 | 0.74 | CTSS (0.47) | GAAEPHX1MMP2MMP1MMP3 | |
| SCHEMBL844823 | 0.74 | CTSS (0.47) | GAAEPHX1MMP2MMP1MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5128448-A | Peptide hormones | HOFFMAN-LA ROCHE INC. (US) | 1992-07-07 | — | — | US | disclosed |