Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.76 |
| ▸ | ABCB1 | P08183 | 5/20 | 0.76 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.76 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.76 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.76 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.76 |
| ▸ | NPC1 | O15118 | 1/20 | 0.76 |
| ▸ | TSHR | P16473 | 1/20 | 0.76 |
| ▸ | CYP1A1 | P04798 | 4/20 | 0.74 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.74 |
| ▸ | MEN1 | O00255 | 3/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.74 |
| ▸ | CYP1B1 | Q16678 | 3/20 | 0.74 |
| ▸ | FTO | Q9C0B1 | 3/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.74 |
| ▸ | GABRP | O00591 | 2/20 | 0.74 |
| ▸ | GABRD | O14764 | 2/20 | 0.74 |
| ▸ | TP53 | P04637 | 2/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31238301 | 0.91 | XDH (0.78) | MAPTABCB1CYP3A4CYP2C9CYP2C19 | |
| Techtochrysin SCHEMBL29494561 | 0.86 | MAPT (1.00) | MAPTABCB1CYP3A4CYP2C9CYP2C19 | |
| Techtochrysin SCHEMBL249043 | 0.86 | MAPT (1.00) | MAPTABCB1CYP3A4CYP2C9CYP2C19 | |
| Chrysin SCHEMBL3453735 | 0.85 | MAPT (1.00) | MAPTABCB1CYP3A4CYP2C9CYP2C19 | |
| Chrysin SCHEMBL29383577 | 0.85 | MAPT (1.00) | MAPTABCB1CYP3A4CYP2C9CYP2C19 | |
| Chrysin SCHEMBL44474 | 0.85 | MAPT (1.00) | MAPTABCB1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL7063538 | 0.85 | MAPT (0.74) | MAPTABCB1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL30192733 | 0.84 | CYP1B1 (0.80) | MAPTABCB1CYP3A4CYP2C9CYP2C19 | |
| Chrysin SCHEMBL10809371 | 0.84 | MAPT (0.97) | MAPTABCB1CYP3A4CYP2C9CYP2C19 | |
| Chrysin SCHEMBL28879361 | 0.84 | MAPT (0.97) | MAPTABCB1CYP3A4CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7875650-B2 | Baicalein analogs; enhances bioavailability of active compounds, especially orally administered compounds, by inhibition of P-glycoprotein 170 (P-gp 170) and/or CYP450 enzyme; 6-Acetoxy-5,7-dihydroxyflavone | YALE UNIVERSITY (US) | 2011-01-25 | — | — | US | disclosed |
| US-20070161605-A1 | Compounds and methods to increase anti-p-glycoprotein activity of baicalein by alkylation on the a ring | YALE UNIVERSITY (US) | 2007-07-12 | — | — | US | disclosed |
| WO-2005075449-A1 | COMPOUNDS AND METHODS TO INCREASE ANTI-P-GLYCOPROTEIN ACTIVITY OF BAICALEIN BY ALKYLATION ON THE A RING | YALE UNIVERSITY (US) | 2005-08-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070161605-A1 | Compounds and methods to increase anti-p-glycoprotein activity of baicalein by alkylation on the a ring | ABCB1, ABCB11, ABCG2 | MAPT 4867/4885ABCB1 1/4885CYP3A4 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.