Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 15/20 | 0.72 |
| ▸ | DRD2 | P14416 | 2/20 | 0.63 |
| ▸ | HTR2A | P28223 | 1/20 | 0.52 |
| ▸ | HTR2C | P28335 | 1/20 | 0.52 |
| ▸ | HTR2B | P41595 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7938644 | 0.99 | HTR1A (0.71) | HTR1ADRD2HTR2AHTR2CHTR2B | |
| Hydrochloric Acid SCHEMBL8900706 | 0.83 | HTR1A (0.98) | HTR1AHTR2AHTR2CHTR2B | |
| SCHEMBL9080563 | 0.68 | HTR1A (1.00) | HTR1ADRD2HTR2AHTR2CHTR2B | |
| SCHEMBL9080567 | 0.68 | HTR1A (1.00) | HTR1ADRD2HTR2AHTR2CHTR2B | |
| Hydrochloric Acid SCHEMBL8900399 | 0.68 | HTR1A (0.97) | HTR1ADRD2HTR2AHTR2CHTR2B | |
| Hydrochloric Acid SCHEMBL8900402 | 0.68 | HTR1A (0.97) | HTR1ADRD2HTR2AHTR2CHTR2B | |
| SCHEMBL8900178 | 0.68 | HTR1A (1.00) | HTR1ADRD2 | |
| SCHEMBL8812201 | 0.67 | HTR1A (0.65) | HTR1AHTR2AHTR2CHTR2B | |
| Hydrochloric Acid SCHEMBL8901004 | 0.67 | HTR1A (0.98) | HTR1ADRD2 | |
| SCHEMBL2049735 | 0.66 | DRD2 (0.53) | HTR1ADRD2HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991000856-A2 | (1,2N) AND (3,2N)-CARBOCYCLIC-2-AMINO TETRALIN DERIVATIVES | THE UPJOHN COMPANY (US) | 1991-01-24 | — | — | WO | claimed |
| EP-0476016-A1 | THERAPEUTICALLY USEFUL 2-AMINOTETRALIN DERIVATIVES | PHARMACIA & UPJOHN COMPANY (US) | 1992-03-25 | — | — | EP | disclosed |
| WO-1990015047-A1 | THERAPEUTICALLY USEFUL 2-AMINOTETRALIN DERIVATIVES | THE UPJOHN COMPANY (US) | 1990-12-13 | — | — | WO | disclosed |