Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 10/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.49 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.43 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | FNTA | P49354 | 1/20 | 0.41 |
| ▸ | FNTB | P49356 | 1/20 | 0.41 |
| ▸ | STS | P08842 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL974325 | 0.83 | HRH3 (0.60) | GPR119HRH3ALKCHEK2KDM1A | |
| SCHEMBL974703 | 0.77 | GPR119 (0.55) | GPR119HRH3ALKCHEK2 | |
| SCHEMBL6671296 | 0.75 | HRH3 (0.57) | GPR119HRH3ALKCHEK2 | |
| SCHEMBL15380030 | 0.73 | PTPN2 (0.61) | GPR119CHEK2STS | |
| SCHEMBL15380031 | 0.73 | PTPN2 (0.61) | GPR119CHEK2STS | |
| SCHEMBL4403540 | 0.73 | HRH3 (0.47) | GPR119HRH3ALKCHEK2KDM1A | |
| SCHEMBL429773 | 0.73 | HRH3 (0.55) | GPR119HRH3ALKCHEK2KDM1A | |
| SCHEMBL31013899 | 0.73 | GPR119 (0.56) | GPR119HRH3ALKCHEK2 | |
| SCHEMBL1795021 | 0.72 | GPR119 (0.61) | GPR119HRH3ALKCHEK2 | |
| SCHEMBL1809399 | 0.72 | GPR119 (0.57) | GPR119HRH3CHEK2KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8754073-B2 | Substituted piperazino-dihydrothienopyrimidines | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-06-17 | — | — | US | disclosed |
| US-20110021501-A1 | SUBSTITUTED PIPERAZINO-DIHYDROTHIENOPYRIMIDINES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-01-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110021501-A1 | SUBSTITUTED PIPERAZINO-DIHYDROTHIENOPYRIMIDINES | DPYD, P2RX1, P2RX5 | GPR119 1759/4885HRH3 110/4885ALK 204/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.