Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB11 | O95342 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.65 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.65 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.65 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.65 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9747268 | 0.85 | ABCB11 (0.63) | ABCB11LMNAPTGS1ADORA1PTGS2 | |
| SCHEMBL4461297 | 0.85 | ABCB11 (0.74) | ABCB11LMNAPTGS1ADORA1PTGS2 | |
| Amfenac SCHEMBL30777846 | 0.81 | ABCB11 (0.78) | ABCB11LMNAPTGS1ADORA1PTGS2 | |
| Amfenac SCHEMBL24249 | 0.81 | ABCB11 (0.78) | ABCB11LMNAPTGS1ADORA1PTGS2 | |
| Bromfenac SCHEMBL28420990 | 0.81 | ABCB11 (0.97) | ABCB11LMNAPTGS1ADORA1PTGS2 | |
| SCHEMBL9749157 | 0.80 | ABCB11 (0.59) | ABCB11LMNAPTGS1ADORA1PTGS2 | |
| Amfenac SCHEMBL9747734 | 0.80 | ABCB11 (0.76) | ABCB11LMNAPTGS1ADORA1PTGS2 | |
| Amfenac SCHEMBL9998546 | 0.80 | ABCB11 (0.76) | ABCB11LMNAPTGS1ADORA1PTGS2 | |
| Amfenac SCHEMBL9747027 | 0.80 | ABCB11 (0.76) | ABCB11LMNAPTGS1ADORA1PTGS2 | |
| Amfenac SCHEMBL11726346 | 0.80 | ABCB11 (0.76) | ABCB11LMNAPTGS1ADORA1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0221753-B1 | TRANSDERMAL TREATMENT FOR PAIN AND INFLAMMATION WITH 2-AMINO-3-AROYLBENZENEACETIC ACIDS, SALTS AND ESTERS | A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) (US) | 1992-01-08 | — | — | EP | claimed |
| US-4683242-A | Transdermal treatment for pain and inflammation with 2-amino-3-aroylbenzeneacetic acids, salts and esters | A. H. ROBINS COMPANY, INCORPORATED (US) | 1987-07-28 | — | — | US | claimed |
| EP-0221753-A2 | Transdermal treatment for pain and inflammation with 2-amino-3-aroylbenzeneacetic acids, salts and esters | A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) (US) | 1987-05-13 | — | — | EP | claimed |