Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | HMGCR | P04035 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3047206 | 0.79 | — | — | |
| SCHEMBL9655412 | 0.75 | — | — | |
| SCHEMBL602183 | 0.75 | — | — | |
| SCHEMBL28591035 | 0.75 | — | — | |
| SCHEMBL600731 | 0.75 | — | — | |
| SCHEMBL600730 | 0.75 | — | — | |
| SCHEMBL17610936 | 0.74 | TSHR (0.36) | TSHRALDH1A1CYP2D6CYP2C19HIF1A | |
| SCHEMBL27747779 | 0.73 | TSHR (0.38) | TSHRALDH1A1CYP2D6CYP2C19HIF1A | |
| SCHEMBL10012423 | 0.73 | CYP2C19 (0.65) | TSHRALDH1A1CYP2D6CYP2C19HIF1A | |
| SCHEMBL379219 | 0.72 | CYP1A2 (0.32) | ALDH1A1CYP2D6CYP2C19CYP1A2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0213293-B1 | 11-Substituted 5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-ones, process for their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1992-01-02 | — | — | EP | disclosed |
| US-4724236-A | FOR TREATING THROMBOEBOLIC DISEASE, BRADYCARDIA OR BRADYARRYTHMIA | KARL THOMAE GMBH (DE) | 1988-02-09 | — | — | US | disclosed |
| EP-0213293-A2 | 11-Substituted 5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-ones, process for their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1987-03-11 | — | — | EP | disclosed |