Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.54 |
| ▸ | LMNA | P02545 | 4/20 | 0.53 |
| ▸ | HPGD | P15428 | 4/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | TOP2A | P11388 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.49 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.49 |
| ▸ | PIK3R1 | P27986 | 4/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9748511 | 0.87 | ALDH1A1 (0.58) | ALDH1A1KDM4ELMNAHPGDHSD17B10 | |
| SCHEMBL9748540 | 0.86 | KDM4E (0.71) | ALDH1A1KDM4ELMNAHPGDHSD17B10 | |
| SCHEMBL9184515 | 0.86 | KDM4E (0.71) | ALDH1A1KDM4ELMNAHPGDHSD17B10 | |
| Hydrochloric Acid SCHEMBL10561159 | 0.85 | KDM4E (0.70) | ALDH1A1KDM4ELMNAHPGDHSD17B10 | |
| SCHEMBL9749228 | 0.84 | ALDH1A1 (0.48) | ALDH1A1KDM4ELMNAHPGDHSD17B10 | |
| SCHEMBL9685920 | 0.84 | ALDH1A1 (0.54) | ALDH1A1KDM4ELMNAHPGDHSD17B10 | |
| SCHEMBL9748102 | 0.84 | ALDH1A1 (0.54) | ALDH1A1KDM4ELMNAHPGDHSD17B10 | |
| SCHEMBL10691007 | 0.84 | ALDH1A1 (0.67) | ALDH1A1KDM4ELMNAHPGDHSD17B10 | |
| SCHEMBL9750235 | 0.84 | ALDH1A1 (0.71) | ALDH1A1KDM4ELMNAHPGDHSD17B10 | |
| SCHEMBL9749538 | 0.84 | DRD3 (0.71) | ALDH1A1KDM4ELMNAHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0215650-B1 | SUBSTITUTED BRIDGED-DIAZABICYCLOALKYL QUINOLONE CARBOXYLIC ACIDS | PFIZER INC. (US) | 1992-01-29 | — | — | EP | disclosed |
| US-4861779-A | Anti-bacterial substituted bridged-diazabicycloalkyl quinolone carboxylic acids | PFIZER INC. (US) | 1989-08-29 | — | — | US | disclosed |
| EP-0215650-A2 | Substituted bridged-diazabicycloalkyl quinolone carboxylic acids | PFIZER INC. (US) | 1987-03-25 | — | — | EP | disclosed |