Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EED | O75530 | 4/20 | 0.51 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | P4HB | P07237 | 1/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | GBA1 | P04062 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27922962 | 0.89 | GBA1 (0.52) | EEDHRH4HRH3GBA1 | |
| SCHEMBL27553990 | 0.83 | HRH3 (0.49) | HRH4HRH3KMT2AALDH1A1MAPT | |
| SCHEMBL14609341 | 0.83 | EED (0.55) | EEDHRH4HRH3KMT2AP2RX7 | |
| SCHEMBL3158864 | 0.83 | EED (0.51) | EEDHRH4HRH3KMT2AGBA1 | |
| SCHEMBL13576618 | 0.83 | KCNH2 (0.53) | EEDHRH4HRH3P2RX7ALDH1A1 | |
| SCHEMBL3467789 | 0.83 | EED (0.51) | EEDHRH4HRH3KMT2AGBA1 | |
| SCHEMBL13576643 | 0.83 | KCNH2 (0.53) | EEDHRH4HRH3P2RX7ALDH1A1 | |
| SCHEMBL3466554 | 0.83 | EED (0.51) | EEDHRH4HRH3KMT2AGBA1 | |
| SCHEMBL1761058 | 0.82 | EED (0.61) | EEDHRH4HRH3KMT2AGBA1 | |
| SCHEMBL3473180 | 0.82 | EED (0.61) | EEDHRH4HRH3KMT2AGBA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0294615-B1 | CYCLOBUTENE-3,4-DIONE-INTERMEDIATES AND THEIR USE IN THE PREPARATION OF HISTAMINE H2-ANTAGONISTS | BRISTOL MYERS SQUIBB CO (US) | 1992-04-15 | — | — | EP | disclosed |
| US-4927970-A | Substituted 3-cyclobutene-1,2-dione intermediates | BRISTOL-MYERS COMPANY (US) | 1990-05-22 | — | — | US | disclosed |
| EP-0294615-A1 | Cyclobutene-3,4-dione-intermediates and their use in the preparation of histamine h2-antagonists | Bristol-Myers Squibb Company (US) | 1988-12-14 | — | — | EP | disclosed |