Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | TOP1 | P11387 | 1/20 | 0.42 |
| ▸ | TOP2A | P11388 | 5/20 | 0.42 |
| ▸ | TOP2B | Q02880 | 5/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | STAT3 | P40763 | 2/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10654313 | 0.90 | KDM4E (0.48) | KDM4EALDH1A1POLBHSP90AA1RXFP1 | |
| SCHEMBL10542756 | 0.86 | KDM4E (0.45) | KDM4EALDH1A1POLBHSP90AA1RXFP1 | |
| SCHEMBL28411452 | 0.86 | KDM4E (0.45) | KDM4EALDH1A1POLBHSP90AA1RXFP1 | |
| SCHEMBL10548946 | 0.86 | KDM4E (0.45) | KDM4EALDH1A1POLBHSP90AA1RXFP1 | |
| SCHEMBL10654436 | 0.80 | KDM4E (0.51) | KDM4EALDH1A1POLBHSP90AA1RXFP1 | |
| SCHEMBL9749468 | 0.80 | KCNH2 (0.51) | KDM4EALDH1A1POLBTOP2ATOP2B | |
| SCHEMBL8733645 | 0.80 | KDM4E (0.43) | KDM4EALDH1A1POLBHSP90AA1RXFP1 | |
| SCHEMBL6213203 | 0.77 | KDM4E (0.51) | KDM4EALDH1A1POLBHSP90AA1RXFP1 | |
| SCHEMBL12917092 | 0.77 | KCNH2 (0.46) | KDM4EALDH1A1POLBHSP90AA1RXFP1 | |
| SCHEMBL500816 | 0.77 | KDM4E (0.61) | KDM4EALDH1A1POLBHSP90AA1RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5091383-A | SUBSTITUTED BRIDGED DIAZABICYCLOALKYL QUINOLONE CARBOXYLIC ACIDS | PFIZER INC. (US) | 1992-02-25 | — | — | US | disclosed |
| EP-0215650-B1 | SUBSTITUTED BRIDGED-DIAZABICYCLOALKYL QUINOLONE CARBOXYLIC ACIDS | PFIZER INC. (US) | 1992-01-29 | — | — | EP | disclosed |
| US-4861779-A | Anti-bacterial substituted bridged-diazabicycloalkyl quinolone carboxylic acids | PFIZER INC. (US) | 1989-08-29 | — | — | US | disclosed |
| US-4775668-A | Substituted bridged-diazabicycloalkyl quinolone carboxylic acids and anti-bacterial use thereof | PFIZER INC. (US) | 1988-10-04 | — | — | US | disclosed |
| EP-0215650-A2 | Substituted bridged-diazabicycloalkyl quinolone carboxylic acids | PFIZER INC. (US) | 1987-03-25 | — | — | EP | disclosed |