Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 6/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | HPGD | P15428 | 5/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.47 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | CLK2 | P49760 | 1/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | TOP2A | P11388 | 3/20 | 0.45 |
| ▸ | TOP2B | Q02880 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9670575 | 0.86 | KCNH2 (0.60) | KCNH2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL9749475 | 0.84 | KDM4E (0.71) | KCNH2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL9749429 | 0.84 | KDM4E (0.67) | KCNH2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL9748530 | 0.80 | KDM4E (0.47) | KCNH2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL9671640 | 0.80 | ALDH1A1 (0.72) | KCNH2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL9522855 | 0.79 | KCNH2 (0.59) | KCNH2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL9634820 | 0.78 | KCNH2 (0.58) | KCNH2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL9666234 | 0.77 | TOP2A (0.61) | KCNH2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL9666037 | 0.76 | ALDH1A1 (0.70) | KCNH2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL9668234 | 0.76 | TOP2A (0.61) | KCNH2KDM4EALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5091383-A | SUBSTITUTED BRIDGED DIAZABICYCLOALKYL QUINOLONE CARBOXYLIC ACIDS | PFIZER INC. (US) | 1992-02-25 | — | — | US | disclosed |
| EP-0215650-B1 | SUBSTITUTED BRIDGED-DIAZABICYCLOALKYL QUINOLONE CARBOXYLIC ACIDS | PFIZER INC. (US) | 1992-01-29 | — | — | EP | disclosed |
| US-4861779-A | Anti-bacterial substituted bridged-diazabicycloalkyl quinolone carboxylic acids | PFIZER INC. (US) | 1989-08-29 | — | — | US | disclosed |
| US-4775668-A | Substituted bridged-diazabicycloalkyl quinolone carboxylic acids and anti-bacterial use thereof | PFIZER INC. (US) | 1988-10-04 | — | — | US | disclosed |
| EP-0215650-A2 | Substituted bridged-diazabicycloalkyl quinolone carboxylic acids | PFIZER INC. (US) | 1987-03-25 | — | — | EP | disclosed |