Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 2/20 | 0.47 |
| ▸ | CES1 | P23141 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.35 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.35 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.35 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.34 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.34 |
| ▸ | ORAI3 | Q9BRQ5 | 1/20 | 0.34 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.34 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11327650 | 0.76 | CES2 (0.54) | CES2CES1TSHRALOX15MAPT | |
| SCHEMBL33953 | 0.68 | CES2 (0.65) | CES2CES1TSHRALOX15MAPT | |
| SCHEMBL9971796 | 0.68 | CES2 (0.65) | CES2CES1TSHRALOX15MAPT | |
| SCHEMBL14119103 | 0.68 | CES2 (0.65) | CES2CES1TSHRALOX15MAPT | |
| SCHEMBL8346950 | 0.68 | CES2 (0.65) | CES2CES1TSHRALOX15MAPT | |
| SCHEMBL14119105 | 0.68 | CES2 (0.65) | CES2CES1TSHRALOX15MAPT | |
| SCHEMBL1073684 | 0.68 | CES2 (0.44) | CES2CES1TSHRALOX15MAPT | |
| SCHEMBL9226914 | 0.67 | CES1 (0.43) | CES2CES1TSHRALOX15MAPT | |
| SCHEMBL401165 | 0.66 | CES2 (0.46) | CES2CES1TSHRALOX15MAPT | |
| SCHEMBL912515 | 0.65 | CES2 (1.00) | CES2CES1TSHRALOX15MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5141937-A | Treatment of hyperlipidemias | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-08-25 | — | — | US | disclosed |
| EP-0308839-A2 | Pharmaceutical composition containing a 7-diphenyl methylene bicycloheptane or a 7-diphenyl methylene bicycloheptene derivative, use of these compounds as medicines, these 7-diphenyl methylene bicycloheptanes and 7-diphenyl bicycloheptenes, and process for their preparation | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-03-29 | — | — | EP | disclosed |